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- W3025102269 endingPage "3507" @default.
- W3025102269 startingPage "3507" @default.
- W3025102269 abstract "Plant-parasitic nematodes secrete a series of effectors to promote parasitism by modulating host immunity, but the detailed molecular mechanism is ambiguous. Animal parasites secrete macrophage migration inhibitory factor (MIF)-like proteins for evasion of host immune systems, in which their biochemical activities play essential roles. Previous research demonstrated that MiMIF-2 effector was secreted by Meloidogyne incognita and modulated host immunity by interacting with annexins. In this study, we show that MiMIF-2 had tautomerase activity and protected nematodes against H2O2 damage. MiMIF-2 expression not only decreased the amount of H2O2 generation during nematode infection in Arabidopsis, but also suppressed Bax-induced cell death by inhibiting reactive oxygen species burst in Nicotiana benthamiana. Further, RNA-seq transcriptome analysis and RT-qPCR showed that the expression of some heat-shock proteins was down regulated in MiMIF-2 transgenic Arabidopsis. After treatment with flg22, RNA-seq transcriptome analysis indicated that the differentially expressed genes in MiMIF-2 expressing Arabidopsis were pointed to plant hormone signal transduction, compound metabolism and plant defense. RT-qPCR and metabolomic results confirmed that salicylic acid (SA) related marker genes and SA content were significantly decreased. Our results provide a comprehensive understanding of how MiMIF-2 modulates plant immunity and broaden knowledge of the intricate relationship between M. incognita and host plants." @default.
- W3025102269 created "2020-05-21" @default.
- W3025102269 creator A5000510528 @default.
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- W3025102269 date "2020-05-15" @default.
- W3025102269 modified "2023-10-17" @default.
- W3025102269 title "MiMIF-2 Effector of Meloidogyne incognita Exhibited Enzyme Activities and Potential Roles in Plant Salicylic Acid Synthesis" @default.
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- W3025102269 doi "https://doi.org/10.3390/ijms21103507" @default.
- W3025102269 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7278917" @default.
- W3025102269 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32429304" @default.
- W3025102269 hasPublicationYear "2020" @default.
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