Matches in SemOpenAlex for { <https://semopenalex.org/work/W3025110747> ?p ?o ?g. }
- W3025110747 endingPage "8422" @default.
- W3025110747 startingPage "8413" @default.
- W3025110747 abstract "Increased expression of some matrix metalloproteinases (MMPs) is closely associated with epilepsy. However, factors that promote their expression have not been clarified. Long noncoding RNAs (lncRNAs) play crucial roles in the development of human diseases, including various cancers, but its potential function in temporal lobe epilepsy (TLE) has remained unexplored. In this study, we showed that hippocampal and serum ILF3-AS1 levels are higher in TLE patients than in matched controls. Interleukin (IL)-1β and tumor necrosis factor (TNF)-α induced ILF3-AS1 expression in astrocytes, while ectopic expression of ILF3-AS1 enhanced IL-6 and TNF-α expression. Ectopic ILF3-AS1 in astrocytes also increased expression of MMP2, MMP3, MMP9 and MMP14, but suppressed expression of miR-212. Consistent with that finding, miR-212 levels were lower in the hippocampus and serum of TLE patients than their controls. This suggests that ILF3-AS1 promotes expression of inflammatory cytokines and MMPs by targeting miR-212 and that ILF3-AS1 plays a crucial role in the development of TLE." @default.
- W3025110747 created "2020-05-21" @default.
- W3025110747 creator A5022821617 @default.
- W3025110747 creator A5027603499 @default.
- W3025110747 creator A5031337173 @default.
- W3025110747 creator A5049958053 @default.
- W3025110747 creator A5058769847 @default.
- W3025110747 creator A5068376674 @default.
- W3025110747 creator A5089220759 @default.
- W3025110747 creator A5090521812 @default.
- W3025110747 date "2020-05-13" @default.
- W3025110747 modified "2023-10-16" @default.
- W3025110747 title "LncRNA ILF3-AS1 mediated the occurrence of epilepsy through suppressing hippocampal miR-212 expression" @default.
- W3025110747 cites W1723491975 @default.
- W3025110747 cites W2044672052 @default.
- W3025110747 cites W2431743365 @default.
- W3025110747 cites W2574014653 @default.
- W3025110747 cites W2582281786 @default.
- W3025110747 cites W2587848828 @default.
- W3025110747 cites W2591727464 @default.
- W3025110747 cites W2593934938 @default.
- W3025110747 cites W2606754742 @default.
- W3025110747 cites W2611846352 @default.
- W3025110747 cites W2614925203 @default.
- W3025110747 cites W2620764443 @default.
- W3025110747 cites W2731123501 @default.
- W3025110747 cites W2753060476 @default.
- W3025110747 cites W2760283151 @default.
- W3025110747 cites W2763440116 @default.
- W3025110747 cites W2763452490 @default.
- W3025110747 cites W2768061708 @default.
- W3025110747 cites W2769394528 @default.
- W3025110747 cites W2773799666 @default.
- W3025110747 cites W2774093947 @default.
- W3025110747 cites W2781665478 @default.
- W3025110747 cites W2788161095 @default.
- W3025110747 cites W2789475629 @default.
- W3025110747 cites W2792763447 @default.
- W3025110747 cites W2797549990 @default.
- W3025110747 cites W2801028794 @default.
- W3025110747 cites W2802166255 @default.
- W3025110747 cites W2804288927 @default.
- W3025110747 cites W2811451736 @default.
- W3025110747 cites W2883780596 @default.
- W3025110747 cites W2883829150 @default.
- W3025110747 cites W2893550716 @default.
- W3025110747 cites W2905271996 @default.
- W3025110747 cites W2910751776 @default.
- W3025110747 cites W2912177640 @default.
- W3025110747 cites W2912302657 @default.
- W3025110747 cites W2915355289 @default.
- W3025110747 cites W2917104731 @default.
- W3025110747 doi "https://doi.org/10.18632/aging.103148" @default.
- W3025110747 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7244033" @default.
- W3025110747 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32404536" @default.
- W3025110747 hasPublicationYear "2020" @default.
- W3025110747 type Work @default.
- W3025110747 sameAs 3025110747 @default.
- W3025110747 citedByCount "24" @default.
- W3025110747 countsByYear W30251107472020 @default.
- W3025110747 countsByYear W30251107472021 @default.
- W3025110747 countsByYear W30251107472022 @default.
- W3025110747 countsByYear W30251107472023 @default.
- W3025110747 crossrefType "journal-article" @default.
- W3025110747 hasAuthorship W3025110747A5022821617 @default.
- W3025110747 hasAuthorship W3025110747A5027603499 @default.
- W3025110747 hasAuthorship W3025110747A5031337173 @default.
- W3025110747 hasAuthorship W3025110747A5049958053 @default.
- W3025110747 hasAuthorship W3025110747A5058769847 @default.
- W3025110747 hasAuthorship W3025110747A5068376674 @default.
- W3025110747 hasAuthorship W3025110747A5089220759 @default.
- W3025110747 hasAuthorship W3025110747A5090521812 @default.
- W3025110747 hasBestOaLocation W30251107471 @default.
- W3025110747 hasConcept C104317684 @default.
- W3025110747 hasConcept C145059251 @default.
- W3025110747 hasConcept C148762608 @default.
- W3025110747 hasConcept C15744967 @default.
- W3025110747 hasConcept C169760540 @default.
- W3025110747 hasConcept C185592680 @default.
- W3025110747 hasConcept C199360897 @default.
- W3025110747 hasConcept C2778186239 @default.
- W3025110747 hasConcept C41008148 @default.
- W3025110747 hasConcept C502942594 @default.
- W3025110747 hasConcept C55493867 @default.
- W3025110747 hasConcept C71924100 @default.
- W3025110747 hasConcept C90559484 @default.
- W3025110747 hasConceptScore W3025110747C104317684 @default.
- W3025110747 hasConceptScore W3025110747C145059251 @default.
- W3025110747 hasConceptScore W3025110747C148762608 @default.
- W3025110747 hasConceptScore W3025110747C15744967 @default.
- W3025110747 hasConceptScore W3025110747C169760540 @default.
- W3025110747 hasConceptScore W3025110747C185592680 @default.
- W3025110747 hasConceptScore W3025110747C199360897 @default.
- W3025110747 hasConceptScore W3025110747C2778186239 @default.
- W3025110747 hasConceptScore W3025110747C41008148 @default.
- W3025110747 hasConceptScore W3025110747C502942594 @default.
- W3025110747 hasConceptScore W3025110747C55493867 @default.
- W3025110747 hasConceptScore W3025110747C71924100 @default.