Matches in SemOpenAlex for { <https://semopenalex.org/work/W3025111305> ?p ?o ?g. }
- W3025111305 endingPage "731" @default.
- W3025111305 startingPage "721" @default.
- W3025111305 abstract "Abstract Intraepithelial T lymphocytes (T-IEL) contain subsets of innate-like T cells that evoke innate and adaptive immune responses to provide rapid protection at epithelial barrier sites. In the intestine, T-IEL express variable T cell antigen receptors (TCR), with unknown antigen specificities. Intriguingly, they also express multiple inhibitory receptors, many of which are normally found on exhausted or antigen-experienced T cells. This pattern suggests that T-IEL are antigen-experienced, yet it is not clear where, and in what context, T-IEL encounter TCR ligands. We review recent evidence indicating TCR antigens for intestinal innate-like T-IEL are found on thymic or intestinal epithelium, driving agonist selection of T-IEL. We explore the contributions of the TCR and various co-stimulatory and co-inhibitory receptors in activating T-IEL effector functions. The balance between inhibitory and activating signals may be key to keeping these highly cytotoxic, rapidly activated cells in check, and key to harnessing their immune surveillance potential." @default.
- W3025111305 created "2020-05-21" @default.
- W3025111305 creator A5015285360 @default.
- W3025111305 creator A5085650562 @default.
- W3025111305 creator A5086332321 @default.
- W3025111305 date "2020-05-15" @default.
- W3025111305 modified "2023-10-15" @default.
- W3025111305 title "Mechanisms of activation of innate-like intraepithelial T lymphocytes" @default.
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