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- W3025117071 abstract "To explore the molecular mechanism of resistance to imatinib in K562 cells(K562-R) and the anti-proliferative effect of oridonin (OR), as well as its mechanism in imatinib-sensitive and imatinib-resistant K562 cells (K562-S and K562-R cells).The expression of p-Lyn in K562-S and K562-R cells were detected by Western blot. The anti-proliferative effect of OR in K562-S and K562-R cells was assayed by MTT, the morphological changes were examined with microscope, the cell apoptosis was detected by flow cytometry, the expressions of BCL-2 and Akt/mTOR signaling pathway were detected by Western blot.The over-expression of p-Lyn was detcected in K562-R cells, OR inhibited the proliferation of K562-S and K562-R cells and the value of IC50 was 4.23±1.30, 4.97±2.23 µmol/L, respectively. The apoptotic rate was obviously enhanced after OR treatment for 24 h, compared with control group. OR down-regulated the expression of p-Lyn, mTOR signaling pathway and BCL-2 protein.Over-expression of p-Lyn may be involved in the mechanism of resistance to imatinib. OR can inhibit the proliferation of K562-S and K562-R cells through down-regulating p-Lyn, inhibiting mTOR signaling pathway and down-regulating expression of BCL-2 protein." @default.
- W3025117071 created "2020-05-21" @default.
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- W3025117071 date "2017-10-01" @default.
- W3025117071 modified "2023-09-28" @default.
- W3025117071 title "[Anti-Leukemia Effect and Mechanism of Oridonin on Imatinib-Sensitive and Imatinib-Resistant K562 Cells]." @default.
- W3025117071 doi "https://doi.org/10.7534/j.issn.1009-2137.2017.05.017" @default.
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