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- W3025119507 abstract "LL37 is an autoantigen derived from keratinocytes that can bind to surface scavenger receptors expressed on myeloid dendritic cells (DCs), plasmacytoid DCs, and macrophages to recognize extracellular self-DNA [ [1] Fabriek B.O. Dijkstra C.D. van den Berg T.K. The macrophage scavenger receptor CD163. Immunobiology. 2005; 210: 153-160 Crossref PubMed Scopus (267) Google Scholar ]. Among such scavenger receptors, CD163 is a specific surface marker of macrophages [ [2] Van Gorp H. Delputte P.L. Nauwynck H.J. Scavenger receptor CD163, a Jack-of-all-trades and potential target for cell-directed therapy. Mol Immunol. 2010; 47: 1650-1660 Crossref PubMed Scopus (223) Google Scholar ]. The expression of LL37 on myeloid cells in the dermis is controlled by proinflammatory cytokines such as IL-17 and TNF-α [ [3] Fuentes-Duculan J. Bonifacio K.M. Hawkes J.E. Kunjravia N. Cueto I. Li X. et al. Autoantigens ADAMTSL5 and LL37 are significantly upregulated in active Psoriasis and localized with keratinocytes, dendritic cells and other leukocytes. Exp Dermatol. 2017; 26: 1075-1082 Crossref PubMed Scopus (49) Google Scholar ]. Since Paget’s cells produce CCL20 and recruit Th17 in the lesional skin of EMPD [ [4] Sato Y. Fujimura T. Tanida K. Lyu C. Matsushita S. Fujisawa Y. et al. Malassezia-derived aryl hydrocarbon receptor (AhR) ligand augments CCL20/Th17/soluble CD163 pathogenic axis in extramammary Paget’s disease. Exp Dermatol. 2019; 28: 933-939 Crossref PubMed Scopus (9) Google Scholar ], the expression of LL37 in invasive EMPD might be increased after the dermal invasion of Paget’s cells. Since TAMs in EMPD secrete an array of chemokines in lesional skin [ [5] Fujimura T. Kambayashi Y. Furudate S. Asano M. Kakizaki A. Aiba S. Receptor Activator of NF-κB Ligand Promotes the Production of CCL17 from RANK+ M2 Macrophages. J Invest Dermatol. 2015; 135: 2884-2887 Abstract Full Text Full Text PDF PubMed Scopus (35) Google Scholar ], TAMs stimulated by LL37 might also play a critical role in the progression of EMPD." @default.
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- W3025119507 date "2020-07-01" @default.
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- W3025119507 title "Increased expression of dermal LL37 may trigger migration of CCR7+ regulatory T cells in extramammary Paget’s disease" @default.
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- W3025119507 doi "https://doi.org/10.1016/j.jdermsci.2020.05.003" @default.
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