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• W3025142703 abstract "Summary of main observation and conclusion Polycyclic fused quinazolinones with anti‐malarial activity were synthesized through tert ‐butyl hydroperoxide (TBHP)‐mediated oxidative decarboxylative cyclization between commercially available isatins and cyclic amines in one step. The reaction proceeds smoothly in water without additional transition‐metal catalyst, acid and base. The newly synthesized products were evaluated to exhibit moderate to good anti‐malarial activity against chloroquine drug‐sensitive Plasmodium falciparum 3D7 strain. Additionally, this method also provides direct approach to Rutaecarpine in good yield." @default.
• W3025142703 created "2020-05-21" @default.
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• W3025142703 date "2020-07-22" @default.
• W3025142703 modified "2023-10-16" @default.
• W3025142703 title "<scp>TBHP‐Mediated</scp> Oxidative Decarboxylative Cyclization in Water: Direct and Sustainable Access to Anti‐malarial Polycyclic Fused Quinazolinones and Rutaecarpine" @default.
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• W3025142703 doi "https://doi.org/10.1002/cjoc.202000154" @default.
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