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• W3025150890 abstract "ABSTRACT The sex-biased disease pulmonary arterial hypertension (PAH) is characterized by the proliferation and overgrowth of dysfunctional pulmonary artery endothelial cells (PAECs). During inflammation associated with PAH, granzyme B cleaves intersectin-1 to produce N-terminal (EHITSN) and C-terminal (SH3A–EITSN) protein fragments. In a murine model of PAH, EHITSN triggers plexiform arteriopathy via p38–ELK1–c-Fos signaling. The SH3A–EITSN fragment also influences signaling, having dominant-negative effects on ERK1 and ERK2 (also known as MAPK3 and MAPK1, respectively). Using PAECs engineered to express tagged versions of EHITSN and SH3A–EITSN, we demonstrate that the two ITSN fragments increase both p38–ELK1 activation and the ratio of p38 to ERK1 and ERK2 activity, leading to PAEC proliferation, with female cells being more responsive than male cells. Furthermore, expression of EHITSN substantially upregulates the expression and activity of the long non-coding RNA Xist in female PAECs, which in turn upregulates the X-linked gene ELK1 and represses expression of krüppel-like factor 2 (KLF2). These events are recapitulated by the PAECs of female idiopathic PAH patients, and may account for their proliferative phenotype. Thus, upregulation of Xist could be an important factor in explaining sexual dimorphism in the proliferative response of PAECs and the imbalanced sex ratio of PAH." @default.
• W3025150890 created "2020-05-21" @default.
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• W3025150890 date "2020-05-01" @default.
• W3025150890 modified "2023-09-27" @default.
• W3025150890 title "Sex differences in the proliferation of pulmonary artery endothelial cells: implications for plexiform arteriopathy" @default.
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• W3025150890 doi "https://doi.org/10.1242/jcs.237776" @default.
• W3025150890 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7240306" @default.
• W3025150890 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32409569" @default.
• W3025150890 hasPublicationYear "2020" @default.
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