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• W3025150992 abstract "Abstract Development of the dorsal aorta is a key step in the establishment of the adult blood-forming system, since hematopoietic stem and progenitor cells (HSPCs) arise from ventral aortic endothelium in all vertebrate animals studied. Work in zebrafish has demonstrated that arterial and venous endothelial precursors arise from distinct subsets of lateral plate mesoderm. Earlier studies in the chick showed that paraxial mesoderm generates another subset of endothelial cells that incorporate into the dorsal aorta to replace HSPCs as they exit the aorta and enter circulation. Here we show that a similar process occurs in the zebrafish, where a population of endothelial precursors delaminates from the somitic dermomyotome to incorporate exclusively into the developing dorsal aorta. Whereas somite-derived endothelial cells (SDECs) lack hematopoietic potential, they act as local niche to support the emergence of HSPCs from neighboring hemogenic endothelium. Thus, at least three subsets of endothelial cells (ECs) contribute to the developing dorsal aorta: vascular ECs, hemogenic ECs, and SDECs. Taken together, our findings indicate that the distinct spatial origins of endothelial precursors dictate different cellular potentials within the developing dorsal aorta." @default.
• W3025150992 created "2020-05-21" @default.
• W3025150992 creator A5009859762 @default.
• W3025150992 creator A5026636531 @default.
• W3025150992 creator A5064380357 @default.
• W3025150992 creator A5071065617 @default.
• W3025150992 date "2020-05-15" @default.
• W3025150992 modified "2023-10-07" @default.
• W3025150992 title "Dermomyotome-derived endothelial cells migrate to the dorsal aorta to support hematopoietic stem cell emergence" @default.
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