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• W3025156346 abstract "Despite the continuous improvement in perioperative use of antibiotics and aseptic techniques, the incidence of infection continues to rise as the need for surgery increasing and brings great challenges to orthopedic surgery. The rough or porous structure of the prosthesis provides an excellent place for bacterial adhesion, proliferation and biofilm formation, which is the main cause of infection. Traditional antibiotic therapy and surgical debridement are difficult to determine whether the infected focus have been removed completely and whether the infection will recur. In recent years, nanotechnology has shown obvious advantages in biomaterials and drug delivery. Nano drug carriers can effectively achieve local antimicrobial therapy, prevent surgical infection by local sustained drug release or intelligent controlled drug release under specific stimuli, and reduce the toxic side effects of drugs. The unique advantages of nanotechnology provide new ideas and options for the prevention and treatment of periprosthetic infection. At present, the application of nano-technology in the prevention and treatment of infection can be divided into the addition of nano-drug-loaded materials to prosthesis materials, the construction of drug-loaded nano-coatings on the surface of prosthesis, the perfusable nano-antimicrobial drug carriers, and the stimulation-responsive drug controlled release system. This article reviews the methods of infection prevention and treatment in orthopaedic surgery, especially the research status of nanotechnology in the prevention and treatment of periprosthetic infection.尽管围手术期抗生素的使用和无菌技术在不断改进，但骨科手术中假体感染仍不可避免，给手术带来巨大挑战。骨科假体表面的粗糙或多孔结构，为细菌黏附、增殖和生物膜形成提供了优良的场所，是导致感染的主要原因。传统的抗生素治疗和清创手术无法完全阻止感染复发。近年来，纳米技术在生物材料、药物输送等方面展现出明显的优势，纳米药物载体能够局部缓释药物或在特定刺激下智能控释药物，可有效实现局部抗菌治疗、预防手术感染，且降低了药物的毒副作用，其独特优势可为感染防治提供新的思路和选择。目前纳米载药系统在防治骨科手术假体感染中的应用主要为骨科假体材料中添加纳米载药材料、假体表面构建载药纳米涂层、可灌注型纳米抗菌药物载体以及刺激响应型药物控释系统。本文综述了目前骨科手术假体感染防治的方法，尤其是纳米载药系统在假体周围感染防治中的研究现状。." @default.
• W3025156346 created "2020-05-21" @default.
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• W3025156346 date "2019-10-25" @default.
• W3025156346 modified "2023-10-17" @default.
• W3025156346 title "[Application of nanodrug carriers in the prevention and treatment of infection around orthopedic prosthesis]." @default.
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• W3025156346 doi "https://doi.org/10.7507/1001-5515.201807032" @default.
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