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- W3025192260 abstract "Abstract Although the anti-diabetic properties of Konjac glucomannan (KGM) have been reported previously; however, the molecular pathways of its anti-diabetic properties are not clear. The present study hypothesized that KGM could mitigate oxidative stress and inflammation. Three doses of KGM (40, 80, 120 mg/kg b.w.) decreased the levels of plasma glucose and insulin in type-2 diabetic rats induced by a high-fat diet and streptozotocin (STZ) after administration for 28 days. Besides, the C-reactive protein, antioxidants, and the pathways of the nuclear factor erythroid 2-related factor 2 (Nrf2) and nuclear factor-kappa B (NF-κB) showed amelioration and positively regulation after treated with a medium dose of KGM (80 mg/kg b.w.). The results of the histological study indicated that the medium dose of KGM was able to reverse the structural impairment of kidney and liver caused by type-2 diabetes. In conclusion, our research demonstrated that KGM reduced the hyperglycemia, regulated the Nrf2 pathway and by which it prevented oxidative stress, besides, it reduced the inflammation via regulation of the NF-kB pathway." @default.
- W3025192260 created "2020-05-21" @default.
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- W3025192260 date "2020-09-01" @default.
- W3025192260 modified "2023-10-14" @default.
- W3025192260 title "In vivo antioxidant and anti-inflammatory effects of soluble dietary fiber Konjac glucomannan in type-2 diabetic rats" @default.
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- W3025192260 doi "https://doi.org/10.1016/j.ijbiomac.2020.05.105" @default.
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