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- W3025200527 endingPage "e9153" @default.
- W3025200527 startingPage "e9153" @default.
- W3025200527 abstract "Breast cancer is a highly frequent and lethal malignancy which metastasis and relapse frequently associates with the existence of breast cancer stem cells (CSCs). CSCs are undifferentiated, aggressive and highly resistant to therapy, with traits modulated by microenvironmental cells and the extracellular matrix (ECM), a biologically complex and dynamic structure composed mainly by type I collagen (Col-I). Col-I enrichment in the tumor-associated ECM leads to microenvironment stiffness and higher tumor aggressiveness and metastatic potential. While Col-I is also known to induce tumor stemness, it is unknown if such effect is dependent of Col-I density. To answer this question, we evaluated the stemness phenotype of MDA-MB-231 and MCF-7 human breast cancer cells cultured within gels of varying Col-I densities. High Col-I density increased CD44 + CD24 − breast cancer stem cell (BCSC) immunophenotype but failed to potentiate Col-I fiber alignment, cell self-renewal and clonogenicity in MDA-MB-231 cells. In MCF-7 cells, high Col-I density decreased total levels of variant CD44 (CD44v). Common to both cell types, high Col-I density induced neither markers related to CSC nor those related with mechanically-induced cell response. We conclude that high Col-I density per se is not sufficient to fully develop the BCSC phenotype." @default.
- W3025200527 created "2020-05-21" @default.
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- W3025200527 date "2020-05-12" @default.
- W3025200527 modified "2023-10-02" @default.
- W3025200527 title "High type I collagen density fails to increase breast cancer stem cell phenotype" @default.
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- W3025200527 cites W1991113366 @default.
- W3025200527 cites W1998259001 @default.
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- W3025200527 cites W2014691022 @default.
- W3025200527 cites W2021750913 @default.
- W3025200527 cites W2023427658 @default.
- W3025200527 cites W2038966527 @default.
- W3025200527 cites W2040430549 @default.
- W3025200527 cites W2053101826 @default.
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- W3025200527 cites W2056992430 @default.
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- W3025200527 doi "https://doi.org/10.7717/peerj.9153" @default.
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- W3025200527 hasPublicationYear "2020" @default.
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