Matches in SemOpenAlex for { <https://semopenalex.org/work/W3025207977> ?p ?o ?g. }
- W3025207977 abstract "ABSTRACT Osteoblasts arise from bone-surrounding connective tissue containing tenocytes and fibroblasts. Lineages of these cell populations and mechanisms of their differentiation are not well understood. Screening enhancer-trap lines of zebrafish allowed us to identify Ebf3 as a transcription factor marking tenocytes and connective tissue cells in skeletal muscle of embryos. Knockout of Ebf3 in mice had no effect on chondrogenesis but led to sternum ossification defects as a result of defective generation of Runx2+ pre-osteoblasts. Conditional and temporal Ebf3 knockout mice revealed requirements of Ebf3 in the lateral plate mesenchyme cells (LPMs), especially in tendon/muscle connective tissue cells, and a stage-specific Ebf3 requirement at embryonic day 9.5-10.5. Upregulated expression of connective tissue markers, such as Egr1/2 and Osr1, increased number of Islet1+ mesenchyme cells, and downregulation of gene expression of the Runx2 regulator Shox2 in Ebf3-deleted thoracic LPMs suggest crucial roles of Ebf3 in the onset of lateral plate mesoderm differentiation towards osteoblasts forming sternum tissues." @default.
- W3025207977 created "2020-05-21" @default.
- W3025207977 creator A5001151045 @default.
- W3025207977 creator A5003488464 @default.
- W3025207977 creator A5004686294 @default.
- W3025207977 creator A5007469250 @default.
- W3025207977 creator A5032375068 @default.
- W3025207977 creator A5034949085 @default.
- W3025207977 creator A5052677090 @default.
- W3025207977 creator A5056735049 @default.
- W3025207977 creator A5057840399 @default.
- W3025207977 creator A5063839561 @default.
- W3025207977 date "2020-05-01" @default.
- W3025207977 modified "2023-10-16" @default.
- W3025207977 title "Transient and lineage-restricted requirement of Ebf3 for sternum ossification" @default.
- W3025207977 cites W1963742875 @default.
- W3025207977 cites W1965428988 @default.
- W3025207977 cites W1981284961 @default.
- W3025207977 cites W1982234682 @default.
- W3025207977 cites W1988824884 @default.
- W3025207977 cites W1997812904 @default.
- W3025207977 cites W2000156083 @default.
- W3025207977 cites W2028135910 @default.
- W3025207977 cites W2041840159 @default.
- W3025207977 cites W2052052041 @default.
- W3025207977 cites W2053071361 @default.
- W3025207977 cites W2059167141 @default.
- W3025207977 cites W2067114363 @default.
- W3025207977 cites W2075234503 @default.
- W3025207977 cites W2096999174 @default.
- W3025207977 cites W2100039503 @default.
- W3025207977 cites W2104135721 @default.
- W3025207977 cites W2117317220 @default.
- W3025207977 cites W2120690411 @default.
- W3025207977 cites W2128051624 @default.
- W3025207977 cites W2133014215 @default.
- W3025207977 cites W2135466817 @default.
- W3025207977 cites W2136970568 @default.
- W3025207977 cites W2141413750 @default.
- W3025207977 cites W2144268541 @default.
- W3025207977 cites W2145655068 @default.
- W3025207977 cites W2145789202 @default.
- W3025207977 cites W2150134228 @default.
- W3025207977 cites W2171370093 @default.
- W3025207977 cites W2171628252 @default.
- W3025207977 cites W2288907347 @default.
- W3025207977 cites W2301861748 @default.
- W3025207977 cites W2597621488 @default.
- W3025207977 cites W2766765760 @default.
- W3025207977 cites W2785603098 @default.
- W3025207977 cites W2792946602 @default.
- W3025207977 cites W2908421620 @default.
- W3025207977 cites W2916020270 @default.
- W3025207977 cites W2939862001 @default.
- W3025207977 cites W2951538476 @default.
- W3025207977 doi "https://doi.org/10.1242/dev.186239" @default.
- W3025207977 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7240299" @default.
- W3025207977 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32398354" @default.
- W3025207977 hasPublicationYear "2020" @default.
- W3025207977 type Work @default.
- W3025207977 sameAs 3025207977 @default.
- W3025207977 citedByCount "6" @default.
- W3025207977 countsByYear W30252079772020 @default.
- W3025207977 countsByYear W30252079772021 @default.
- W3025207977 countsByYear W30252079772022 @default.
- W3025207977 crossrefType "journal-article" @default.
- W3025207977 hasAuthorship W3025207977A5001151045 @default.
- W3025207977 hasAuthorship W3025207977A5003488464 @default.
- W3025207977 hasAuthorship W3025207977A5004686294 @default.
- W3025207977 hasAuthorship W3025207977A5007469250 @default.
- W3025207977 hasAuthorship W3025207977A5032375068 @default.
- W3025207977 hasAuthorship W3025207977A5034949085 @default.
- W3025207977 hasAuthorship W3025207977A5052677090 @default.
- W3025207977 hasAuthorship W3025207977A5056735049 @default.
- W3025207977 hasAuthorship W3025207977A5057840399 @default.
- W3025207977 hasAuthorship W3025207977A5063839561 @default.
- W3025207977 hasBestOaLocation W30252079771 @default.
- W3025207977 hasConcept C104317684 @default.
- W3025207977 hasConcept C105702510 @default.
- W3025207977 hasConcept C127561419 @default.
- W3025207977 hasConcept C127716648 @default.
- W3025207977 hasConcept C145103041 @default.
- W3025207977 hasConcept C162407555 @default.
- W3025207977 hasConcept C164659718 @default.
- W3025207977 hasConcept C198826908 @default.
- W3025207977 hasConcept C2776340970 @default.
- W3025207977 hasConcept C2776363554 @default.
- W3025207977 hasConcept C2778842504 @default.
- W3025207977 hasConcept C2780915607 @default.
- W3025207977 hasConcept C35496256 @default.
- W3025207977 hasConcept C518705261 @default.
- W3025207977 hasConcept C54355233 @default.
- W3025207977 hasConcept C86339819 @default.
- W3025207977 hasConcept C86803240 @default.
- W3025207977 hasConcept C95444343 @default.
- W3025207977 hasConceptScore W3025207977C104317684 @default.
- W3025207977 hasConceptScore W3025207977C105702510 @default.
- W3025207977 hasConceptScore W3025207977C127561419 @default.
- W3025207977 hasConceptScore W3025207977C127716648 @default.
- W3025207977 hasConceptScore W3025207977C145103041 @default.