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- W3025214597 endingPage "104892" @default.
- W3025214597 startingPage "104892" @default.
- W3025214597 abstract "This is the first work to load HPMC and PVP by the lansoprazole (LPZ) through supercritical solvent impregnation (SSI). The process was carried out at laboratory scale under various sets of conditions in terms of pressure (150−250 bar), temperature (308−328 K), and impregnation time (60−180 min). The results showed that an increase in any of the investigated parameters increased the drug loading, and that the temperature imposed the strongest effect on the drug loading. Moreover, impregnation loadings onto the PVP and HPMC were found to range from 0.56% to 0.61% and from 1.16% to 1.30%, respectively. For both polymers, the best results were obtained at a pressure of 250 bar and a temperature of 328 K with an impregnation time of 180 min. The processed drug was further investigated by XRD, SEM, DSC, FTIR, and DLS analyses. The final results indicated superior loading of the drug onto the HPMC rather than the PVP." @default.
- W3025214597 created "2020-05-21" @default.
- W3025214597 creator A5039504671 @default.
- W3025214597 creator A5065137518 @default.
- W3025214597 creator A5067759329 @default.
- W3025214597 date "2020-10-01" @default.
- W3025214597 modified "2023-10-16" @default.
- W3025214597 title "Lansoprazole loading of polymers by supercritical carbon dioxide impregnation: Impacts of process parameters" @default.
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