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• W3025243329 abstract "ABSTRACT Objective The goal of this work was to develop a physiology-based paradigm for pulse selection from electrodermal activity (EDA) data. Methods We aimed to use insight about the integrate-and-fire physiology of sweat gland bursts, which predicts inverse Gaussian inter-pulse interval structure. At the core of our paradigm is a subject-specific amplitude threshold selection process for pulses based on the statistical properties of four right-skewed models including the inverse Gaussian. These four models differ in their tail behavior, which reflects sweat gland physiology to varying degrees. By screening across thresholds and fitting all four models, we selected for heavier tails that reflect inverse Gaussian-like structure and verified the pulse selection with a goodness-of-fit analysis. Results We tested our paradigm on two different subject cohorts recorded during different experimental conditions and using different equipment. In both cohorts, our method robustly and consistently recovered pulses that captured the inverse Gaussian-like structure predicted by physiology, despite large differences in noise level of the data. In contrast, an established EDA analysis paradigm, which assumes a constant amplitude threshold across all data, was unable to separate pulses from noise. Conclusion We present a computationally efficient, statistically rigorous, and physiology-informed paradigm for pulse selection from EDA data that is robust across individuals and experimental conditions yet adaptable to changes in noise level. Significance The robustness of our paradigm and its basis in physiology move EDA closer to serving as a clinical marker for sympathetic activity in diverse conditions such as pain, anxiety, depression, and sleep." @default.
• W3025243329 created "2020-05-21" @default.
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• W3025243329 date "2020-05-19" @default.
• W3025243329 modified "2023-09-23" @default.
• W3025243329 title "A Model-Based Approach for Pulse Selection from Electrodermal Activity" @default.
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• W3025243329 doi "https://doi.org/10.1101/2020.05.17.098129" @default.
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