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- W3025244400 abstract "Several studies have revealed a positive association between methylenetetrahydrofolate reductase (MTHFR) single nucleotide polymorphism 677C > T and schizophrenia. In T-allele carriers the functional activity of MTHFR is reduced contributing to hyperhomocysteinemia development, methionine deficiency and as a consequence - redox dysregulation and the alteration of dopamine synthesis. The aim of this study was to investigate the association of MTHFR677C > T with the severity of extrapyramidal side effects of antipsychotics in schizophrenia. The average score on the Simpson-Angus scale (SAS) in a group of patients with MTHFR 677 T-allele (n = 30; 13.27 ± 5.10, M ± SD) was statistically significantly higher (t = −2.40; p = 0.02) than in the comparison group of wild genotype MTHFR 677 CC carriers (n = 31; 9.84 ± 6.03, M ± SD), confirming the working hypothesis about a possible association of the MTHFR677 T-allele carriage with the development of extrapyramidal side effects of antipsychotics. • MTHFR677C > T is associated with antipsychotic-induced parkinsonism in schizophrenia. • It's association with other types of EPS needs further exploration. • It's association with negative symptoms of schizophrenia may be mediated by EPS." @default.
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- W3025244400 date "2020-09-01" @default.
- W3025244400 modified "2023-10-14" @default.
- W3025244400 title "Association of MTHFR 677C > T genetic polymorphism with extrapyramidal side effects of antipsychotic treatment" @default.
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- W3025244400 doi "https://doi.org/10.1016/j.genrep.2020.100717" @default.
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