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• W3025261643 startingPage "3455" @default.
• W3025261643 abstract "Evidence support that brain membrane fatty acids play a crucial role in psychopathologies such as depression and anxiety disorders. Although the pathogenesis of depression is not still defined, drugs commonly used to reduce arachidonic turnover in the brain can control mood disorders, such as depression. Both astrocytes and mast cells release arachidonic acid during silent inflammation. Here, we hypothesize that arachidonic acid freed from lipid droplets of mast cells, as well as the one released from activated astrocytes, could contribute to characterize a depressive condition, and the fatty acids profile of mast cells, astrocytes and microglia could also vary, reflecting the pathophysiological depressive state of the subject. Finally, there is evidence that gut microbiota is deeply implicated in mood and behavioral disorders. Human gut microbiota can control nervous system diseases through neuroimmune pathways." @default.
• W3025261643 created "2020-05-21" @default.
• W3025261643 creator A5012000066 @default.
• W3025261643 creator A5026736591 @default.
• W3025261643 date "2020-05-17" @default.
• W3025261643 modified "2023-10-17" @default.
• W3025261643 title "Mast Cells, Astrocytes, Arachidonic Acid: Do They Play a Role in Depression?" @default.
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• W3025261643 doi "https://doi.org/10.3390/app10103455" @default.
• W3025261643 hasPublicationYear "2020" @default.
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