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- W3025269435 endingPage "6175" @default.
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- W3025269435 abstract "Differentially substituted 1,2-amino alcohols are a prevalent motif in a variety of pharmaceutical and agrochemical molecules. Dynamic kinetic resolutions (DKRs) that involve the asymmetric reduction of α-amino ketones are attractive for preparing this motif; however, methods for racemizing the stereogenic α-carbon under mild conditions are underdeveloped. Here we report a chemoenzymatic DKR involving ketoreductases (KREDs), in which pyridoxal-5-phosphate (PLP) is used to catalyze racemization of the starting racemic α-aminoketone. This strategy enables access to a variety of 1,2-amino alcohols with high levels of diastereo- and enantioselectivity. Using commercially available KREDs, all four possible stereoisomers can be accessed, highlighting a benefit to this approach." @default.
- W3025269435 created "2020-05-21" @default.
- W3025269435 creator A5010418479 @default.
- W3025269435 creator A5087675755 @default.
- W3025269435 date "2020-05-11" @default.
- W3025269435 modified "2023-10-18" @default.
- W3025269435 title "Pyridoxal-Catalyzed Racemization of α-Aminoketones Enables the Stereodivergent Synthesis of 1,2-Amino Alcohols Using Ketoreductases" @default.
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- W3025269435 doi "https://doi.org/10.1021/acscatal.0c01502" @default.
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