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- W3025274073 abstract "Adaptation to hypoxia is a common feature in solid tumors orchestrated by oxygen-dependent and independent upregulation of the hypoxia-inducible factor-1α (HIF-1α). We unveiled that G protein-coupled receptor kinase (GRK2), known to be overexpressed in certain tumors, fosters this hypoxic pathway via phosphorylation of the mRNA-binding protein HuR, a central HIF-1α modulator. GRK2-mediated HuR phosphorylation increases the total levels and cytoplasmic shuttling of HuR in response to hypoxia, and GRK2-phosphodefective HuR mutants show defective cytosolic accumulation and lower binding to HIF-1α mRNA in hypoxic Hela cells. Interestingly, enhanced GRK2 and HuR expression correlate in luminal breast cancer patients. GRK2 also promotes the HuR/HIF-1α axis and VEGF-C accumulation in normoxic MCF7 breast luminal cancer cells and is required for the induction of HuR/HIF1-α in response to adrenergic stress. Our results point to a relevant role of the GRK2/HuR/HIF-1α module in the adaptation of malignant cells to tumor microenvironment-related stresses." @default.
- W3025274073 created "2020-05-21" @default.
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- W3025274073 date "2020-05-13" @default.
- W3025274073 modified "2023-10-18" @default.
- W3025274073 title "GRK2-Dependent HuR Phosphorylation Regulates HIF1α Activation under Hypoxia or Adrenergic Stress" @default.
- W3025274073 cites W1543974788 @default.
- W3025274073 cites W1658942426 @default.
- W3025274073 cites W1718435705 @default.
- W3025274073 cites W1977629626 @default.
- W3025274073 cites W1979197099 @default.
- W3025274073 cites W1979770213 @default.
- W3025274073 cites W1991298929 @default.
- W3025274073 cites W1993717649 @default.
- W3025274073 cites W1997259050 @default.
- W3025274073 cites W2001724396 @default.
- W3025274073 cites W2013937234 @default.
- W3025274073 cites W2029260884 @default.
- W3025274073 cites W2030248691 @default.
- W3025274073 cites W2033180466 @default.
- W3025274073 cites W2048085228 @default.
- W3025274073 cites W2049462796 @default.
- W3025274073 cites W2055758127 @default.
- W3025274073 cites W2056207617 @default.
- W3025274073 cites W2059000751 @default.
- W3025274073 cites W2064513293 @default.
- W3025274073 cites W2065844087 @default.
- W3025274073 cites W2073535977 @default.
- W3025274073 cites W2076232466 @default.
- W3025274073 cites W2085555782 @default.
- W3025274073 cites W2086963800 @default.
- W3025274073 cites W2095609506 @default.
- W3025274073 cites W2099518931 @default.
- W3025274073 cites W2108090987 @default.
- W3025274073 cites W2111129415 @default.
- W3025274073 cites W2111685937 @default.
- W3025274073 cites W2113720860 @default.
- W3025274073 cites W2115931493 @default.
- W3025274073 cites W2123049006 @default.
- W3025274073 cites W2124834682 @default.
- W3025274073 cites W2124987847 @default.
- W3025274073 cites W2127509018 @default.
- W3025274073 cites W2128019786 @default.
- W3025274073 cites W2128720796 @default.
- W3025274073 cites W2133590393 @default.
- W3025274073 cites W2135070076 @default.
- W3025274073 cites W2141382054 @default.
- W3025274073 cites W2142786915 @default.
- W3025274073 cites W2148301527 @default.
- W3025274073 cites W2154925328 @default.
- W3025274073 cites W2157502876 @default.
- W3025274073 cites W2160399906 @default.
- W3025274073 cites W2164882597 @default.
- W3025274073 cites W2217032169 @default.
- W3025274073 cites W2291657574 @default.
- W3025274073 cites W2297401822 @default.
- W3025274073 cites W2318001050 @default.
- W3025274073 cites W2324147750 @default.
- W3025274073 cites W2340296670 @default.
- W3025274073 cites W2343575524 @default.
- W3025274073 cites W2440773800 @default.
- W3025274073 cites W2460366155 @default.
- W3025274073 cites W2510629815 @default.
- W3025274073 cites W2521583908 @default.
- W3025274073 cites W2527917170 @default.
- W3025274073 cites W2537974699 @default.
- W3025274073 cites W2552872119 @default.
- W3025274073 cites W2566243011 @default.
- W3025274073 cites W2594370808 @default.
- W3025274073 cites W2596572267 @default.
- W3025274073 cites W2610657571 @default.
- W3025274073 cites W2612263474 @default.
- W3025274073 cites W2714953920 @default.
- W3025274073 cites W2734989022 @default.
- W3025274073 cites W2767490296 @default.
- W3025274073 cites W2770247709 @default.
- W3025274073 cites W2792290811 @default.
- W3025274073 cites W2803972087 @default.
- W3025274073 cites W2892157955 @default.
- W3025274073 cites W2899621095 @default.
- W3025274073 cites W2902207260 @default.
- W3025274073 cites W2921552993 @default.
- W3025274073 cites W2924841425 @default.
- W3025274073 cites W2946642373 @default.
- W3025274073 cites W2969442898 @default.
- W3025274073 cites W2977993316 @default.
- W3025274073 cites W840198816 @default.
- W3025274073 doi "https://doi.org/10.3390/cancers12051216" @default.
- W3025274073 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7281538" @default.