FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3025274282> ?p ?o ?g. }

• W3025274282 endingPage "190" @default.
• W3025274282 startingPage "179" @default.
• W3025274282 abstract "Amoxicillin is a common pediatric drug. However, to the best of our knowledge, the role of amoxicillin in enamel hypomineralization has not yet been fully elucidated. The aim of the present study was to assess the effects of amoxicillin on enamel mineralization, the morphology of ameloblasts, as well as the expression of kallikrein‑related peptidase 4 (KLK4), and the tight junction proteins, claudin 1 (CLDN1), claudin 4 (CLDN4) and occludin (OCLN), in ameloblasts of juvenile mice. A total of 36 3‑day‑old Kunming mice were randomly divided into three groups. The mice were administered 0, 50 or 100 mg/kg amoxicillin by intragastric administration for 19 days. The surface morphology and calcium (Ca), phosphorous (P) and carbon contents of mandibular incisors and first molars were examined by scanning electron microscopy and energy dispersive X‑ray spectroscopy. Histological changes in the ameloblasts of mandibular incisors were analyzed by hematoxylin and eosin staining. The KLK4, CLDN1, CLDN4 and OCLN expression levels of ameloblasts were observed by immunohistochemical staining. The incidence of white patches in the incisor was 100% in the 100 mg/kg amoxicillin‑treated groups. A greater number of enamel defects were observed in the incisal/occlusal half of mandibular incisors/molars compared with in the cervical half in the amoxicillin‑treated groups. Following phosphoric‑acid treatment, the enamel rod and interrod were aligned in a disorderly manner in the amoxicillin‑treated groups. Amoxicillin decreased the Ca/P ratio in the enamel of mandibular incisors and molars. More intercellular spaces among maturation ameloblasts were observed in the amoxicillin‑treated groups. Amoxicillin decreased KLK4 and CLDN1, CLDN4 and OCLN expression in mature ameloblasts. The administration of amoxicillin in juvenile mice induced enamel hypomineralization, and the effects of amoxicillin on enamel hypomineralization may be mediated via multiple pathways." @default.
• W3025274282 created "2020-05-21" @default.
• W3025274282 creator A5001333423 @default.
• W3025274282 creator A5020104819 @default.
• W3025274282 creator A5025115516 @default.
• W3025274282 creator A5031071078 @default.
• W3025274282 creator A5032909562 @default.
• W3025274282 creator A5047718865 @default.
• W3025274282 creator A5067341242 @default.
• W3025274282 creator A5067851200 @default.
• W3025274282 creator A5078894109 @default.
• W3025274282 creator A5088664989 @default.
• W3025274282 date "2020-05-12" @default.
• W3025274282 modified "2023-09-29" @default.
• W3025274282 title "Effects of applying amoxicillin in juvenile mice on enamel mineralization and the expression of kallikrein‑related peptidase 4 and tight junction proteins in ameloblasts" @default.
• W3025274282 cites W1772573500 @default.
• W3025274282 cites W1861586320 @default.
• W3025274282 cites W1887937005 @default.
• W3025274282 cites W1972489919 @default.
• W3025274282 cites W1976402118 @default.
• W3025274282 cites W1981760537 @default.
• W3025274282 cites W1996497944 @default.
• W3025274282 cites W2010136189 @default.
• W3025274282 cites W2030710208 @default.
• W3025274282 cites W2034623430 @default.
• W3025274282 cites W2038097111 @default.
• W3025274282 cites W2051320204 @default.
• W3025274282 cites W2061337534 @default.
• W3025274282 cites W2062784925 @default.
• W3025274282 cites W2085008302 @default.
• W3025274282 cites W2094850843 @default.
• W3025274282 cites W2095979195 @default.
• W3025274282 cites W2103503126 @default.
• W3025274282 cites W2103925175 @default.
• W3025274282 cites W2105482959 @default.
• W3025274282 cites W2106428012 @default.
• W3025274282 cites W2108985324 @default.
• W3025274282 cites W2124676521 @default.
• W3025274282 cites W2149303529 @default.
• W3025274282 cites W2167913984 @default.
• W3025274282 cites W2189105939 @default.
• W3025274282 cites W2252640115 @default.
• W3025274282 cites W2332398369 @default.
• W3025274282 cites W2345775890 @default.
• W3025274282 cites W2355724288 @default.
• W3025274282 cites W2417157940 @default.
• W3025274282 cites W2464915778 @default.
• W3025274282 cites W2512479677 @default.
• W3025274282 cites W2611809716 @default.
• W3025274282 cites W2618650982 @default.
• W3025274282 cites W2740025977 @default.
• W3025274282 cites W4211146028 @default.
• W3025274282 doi "https://doi.org/10.3892/ijmm.2020.4598" @default.
• W3025274282 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7255463" @default.
• W3025274282 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32626909" @default.
• W3025274282 hasPublicationYear "2020" @default.
• W3025274282 type Work @default.
• W3025274282 sameAs 3025274282 @default.
• W3025274282 citedByCount "1" @default.
• W3025274282 countsByYear W30252742822021 @default.
• W3025274282 crossrefType "journal-article" @default.
• W3025274282 hasAuthorship W3025274282A5001333423 @default.
• W3025274282 hasAuthorship W3025274282A5020104819 @default.
• W3025274282 hasAuthorship W3025274282A5025115516 @default.
• W3025274282 hasAuthorship W3025274282A5031071078 @default.
• W3025274282 hasAuthorship W3025274282A5032909562 @default.
• W3025274282 hasAuthorship W3025274282A5047718865 @default.
• W3025274282 hasAuthorship W3025274282A5067341242 @default.
• W3025274282 hasAuthorship W3025274282A5067851200 @default.
• W3025274282 hasAuthorship W3025274282A5078894109 @default.
• W3025274282 hasAuthorship W3025274282A5088664989 @default.
• W3025274282 hasBestOaLocation W30252742821 @default.
• W3025274282 hasConcept C104392178 @default.
• W3025274282 hasConcept C111696902 @default.
• W3025274282 hasConcept C115961737 @default.
• W3025274282 hasConcept C156887251 @default.
• W3025274282 hasConcept C159750122 @default.
• W3025274282 hasConcept C185592680 @default.
• W3025274282 hasConcept C18903297 @default.
• W3025274282 hasConcept C190283241 @default.
• W3025274282 hasConcept C199343813 @default.
• W3025274282 hasConcept C2779708577 @default.
• W3025274282 hasConcept C2781018059 @default.
• W3025274282 hasConcept C29537977 @default.
• W3025274282 hasConcept C501593827 @default.
• W3025274282 hasConcept C54355233 @default.
• W3025274282 hasConcept C55493867 @default.
• W3025274282 hasConcept C71924100 @default.
• W3025274282 hasConcept C86803240 @default.
• W3025274282 hasConcept C89423630 @default.
• W3025274282 hasConcept C95444343 @default.
• W3025274282 hasConceptScore W3025274282C104392178 @default.
• W3025274282 hasConceptScore W3025274282C111696902 @default.
• W3025274282 hasConceptScore W3025274282C115961737 @default.
• W3025274282 hasConceptScore W3025274282C156887251 @default.
• W3025274282 hasConceptScore W3025274282C159750122 @default.
• W3025274282 hasConceptScore W3025274282C185592680 @default.
• W3025274282 hasConceptScore W3025274282C18903297 @default.

• next