Matches in SemOpenAlex for { <https://semopenalex.org/work/W3025300788> ?p ?o ?g. }
- W3025300788 endingPage "51" @default.
- W3025300788 startingPage "51" @default.
- W3025300788 abstract "The ataxia-telangiectasia-mutated (ATM) and ataxia-telangiectasia-mutated and Rad3-related (ATR) DNA damage repair pathways serve as the surveillance system which keeps a check on different types of DNA damages and lesions, which includes DNA single-strand breaks, DNA double-strand breaks and other aberrant structures such as arrested replication forks during replication. The ATM and ATR kinases belong to PIKK class of kinases which activate a large number of downstream mediator and effector molecules. The main classes of effector kinases activated by ATM and ATR are checkpoint kinase 2 and checkpoint kinase 1, respectively. ATR works primarily with the RAD9-RAD1-HUS1 (9-1-1) complex, whereas ATM works with the MRE11– RAD50–NBS1 complex. Together ATM and ATR kinase protects the cells' genomic integrity and prevents random mutations to be carried into their progeny." @default.
- W3025300788 created "2020-05-21" @default.
- W3025300788 creator A5003084332 @default.
- W3025300788 creator A5008203100 @default.
- W3025300788 creator A5038883739 @default.
- W3025300788 creator A5042345617 @default.
- W3025300788 date "2020-01-01" @default.
- W3025300788 modified "2023-10-16" @default.
- W3025300788 title "ATM and ATR checkpoint kinase pathways: A concise review" @default.
- W3025300788 cites W1480741751 @default.
- W3025300788 cites W1491129208 @default.
- W3025300788 cites W1512321076 @default.
- W3025300788 cites W1518974235 @default.
- W3025300788 cites W1541806623 @default.
- W3025300788 cites W1570361288 @default.
- W3025300788 cites W1618806168 @default.
- W3025300788 cites W1633875338 @default.
- W3025300788 cites W1967012607 @default.
- W3025300788 cites W1967630574 @default.
- W3025300788 cites W1967743500 @default.
- W3025300788 cites W1968469516 @default.
- W3025300788 cites W1968516742 @default.
- W3025300788 cites W1968552183 @default.
- W3025300788 cites W1972542332 @default.
- W3025300788 cites W1974682687 @default.
- W3025300788 cites W1976558883 @default.
- W3025300788 cites W1979015046 @default.
- W3025300788 cites W1981504084 @default.
- W3025300788 cites W1983356442 @default.
- W3025300788 cites W1984373702 @default.
- W3025300788 cites W1986162414 @default.
- W3025300788 cites W1986179131 @default.
- W3025300788 cites W1987577420 @default.
- W3025300788 cites W1988756673 @default.
- W3025300788 cites W1988876917 @default.
- W3025300788 cites W1991221096 @default.
- W3025300788 cites W1992294575 @default.
- W3025300788 cites W1992783176 @default.
- W3025300788 cites W1994954342 @default.
- W3025300788 cites W1995979224 @default.
- W3025300788 cites W1999644099 @default.
- W3025300788 cites W2000303122 @default.
- W3025300788 cites W2001764241 @default.
- W3025300788 cites W2006705573 @default.
- W3025300788 cites W2007935491 @default.
- W3025300788 cites W2008932845 @default.
- W3025300788 cites W2009779043 @default.
- W3025300788 cites W2018507091 @default.
- W3025300788 cites W2018884388 @default.
- W3025300788 cites W2019292967 @default.
- W3025300788 cites W2020084014 @default.
- W3025300788 cites W2020679229 @default.
- W3025300788 cites W2022811243 @default.
- W3025300788 cites W2023620387 @default.
- W3025300788 cites W2025011614 @default.
- W3025300788 cites W2027733273 @default.
- W3025300788 cites W2028044172 @default.
- W3025300788 cites W2029023135 @default.
- W3025300788 cites W2029934390 @default.
- W3025300788 cites W2031203839 @default.
- W3025300788 cites W2031414445 @default.
- W3025300788 cites W2033172828 @default.
- W3025300788 cites W2038811166 @default.
- W3025300788 cites W2043027414 @default.
- W3025300788 cites W2043136696 @default.
- W3025300788 cites W2043895957 @default.
- W3025300788 cites W2045041347 @default.
- W3025300788 cites W2050293032 @default.
- W3025300788 cites W2054373762 @default.
- W3025300788 cites W2054889035 @default.
- W3025300788 cites W2057949133 @default.
- W3025300788 cites W2059365987 @default.
- W3025300788 cites W2061060103 @default.
- W3025300788 cites W2062284662 @default.
- W3025300788 cites W2067022597 @default.
- W3025300788 cites W2067804796 @default.
- W3025300788 cites W2071457560 @default.
- W3025300788 cites W2076314401 @default.
- W3025300788 cites W2078242581 @default.
- W3025300788 cites W2079116990 @default.
- W3025300788 cites W2082078734 @default.
- W3025300788 cites W2084089807 @default.
- W3025300788 cites W2084883784 @default.
- W3025300788 cites W2087110475 @default.
- W3025300788 cites W2089574530 @default.
- W3025300788 cites W2092675732 @default.
- W3025300788 cites W2097805947 @default.
- W3025300788 cites W2098444271 @default.
- W3025300788 cites W2098935972 @default.
- W3025300788 cites W2100285961 @default.
- W3025300788 cites W2101942126 @default.
- W3025300788 cites W2105592350 @default.
- W3025300788 cites W2111403239 @default.
- W3025300788 cites W2113780833 @default.
- W3025300788 cites W2120897498 @default.
- W3025300788 cites W2120921507 @default.
- W3025300788 cites W2124704844 @default.
- W3025300788 cites W2125299927 @default.