FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3025317959> ?p ?o ?g. }

• W3025317959 abstract "Background: Neuromyelitis optica spectrum disorders (NMOSD) are severe inflammatory demyelinating disorders of the central nervous system mainly characterized by recurrent episodes of uni- or bilateral optic neuritis (ON), transverse myelitis (TM) and brainstem syndromes (BS). The majority of adult patients has serum antibodies directed against the water channel protein aquaporin 4 (AQP4-abs). In paediatric patients, AQP4-abs are less, while antibodies against myelin oligodendrocyte glycoprotein (MOG-abs) are more frequently detectable than in adults. Some children with NMOSD have neither AQP4- nor MOG-ab (double-seronegative). Objective: Evaluation of epidemiological data regarding incidence and prevalence of paediatric NMOSD in Germany and Austria. Methods: We recruited paediatric NMOSD patients between 1 March 2017 and 28 February 2019 with five different tools: (1) ESPED (Surveillance Unit for Rare Paediatric Disorders in Germany), (2) ESNEK (Surveillance for Rare Neurological Disorders during Childhood), (3) paediatric neurology working group within the Austrian Society of Paediatrics and Adolescent Medicine, (4) BIOMARKER Study and (5) NEMOS (Neuromyelitis optica Study Group). We requested data regarding clinical symptoms, antibody status, therapy regimen and response via a standardized questionnaire. Results: During the two-year recruitment period, 46 (both incidental and prevalent) patients with a suspected diagnosis of NMOSD were brought to our attention. Twenty-two of these patients did not fulfil the inclusion criteria. Of the remaining 24 children, 22 had a median age at onset of 11 (range 3-17) years and 16/22 were female (72.7%) (no data in two patients). Sixteen of 24 patients were AQP4-ab positive (67%), 4/24 MOG-ab positive (16.7%), three children were double-seronegative and in one patient no antibody testing was done. We calculated an incidence rate of 0.022 per 100,000 person-years for Germany, while there was no incidental case in Austria during the recruitment period. The prevalence rate was 0.147 and 0.267 per 100,000 persons in Germany and Austria respectively. Conclusion: Paediatric NMOSD, with and without associated antibodies, are very rare even considering the different limitations of our study. An unexpected finding was that a considerable proportion of patients was tested neither for AQP4- nor MOG-abs during diagnostic work-up, which should prompt to establish and disseminate appropriate guidelines." @default.
• W3025317959 created "2020-05-21" @default.
• W3025317959 creator A5002804657 @default.
• W3025317959 creator A5013773031 @default.
• W3025317959 creator A5027452122 @default.
• W3025317959 creator A5053295756 @default.
• W3025317959 creator A5055451113 @default.
• W3025317959 creator A5060641186 @default.
• W3025317959 creator A5064745136 @default.
• W3025317959 creator A5075442778 @default.
• W3025317959 date "2020-05-15" @default.
• W3025317959 modified "2023-10-08" @default.
• W3025317959 title "Epidemiology of Pediatric NMOSD in Germany and Austria" @default.
• W3025317959 cites W1972144029 @default.
• W3025317959 cites W1979550850 @default.
• W3025317959 cites W1990157891 @default.
• W3025317959 cites W1995773404 @default.
• W3025317959 cites W1998149314 @default.
• W3025317959 cites W2006660240 @default.
• W3025317959 cites W2007502293 @default.
• W3025317959 cites W2015166851 @default.
• W3025317959 cites W2026497829 @default.
• W3025317959 cites W2038941725 @default.
• W3025317959 cites W2040792196 @default.
• W3025317959 cites W2042517646 @default.
• W3025317959 cites W2044637498 @default.
• W3025317959 cites W2055391010 @default.
• W3025317959 cites W2064199099 @default.
• W3025317959 cites W2072799381 @default.
• W3025317959 cites W2080476124 @default.
• W3025317959 cites W2091934359 @default.
• W3025317959 cites W2094929674 @default.
• W3025317959 cites W2095649605 @default.
• W3025317959 cites W2095982496 @default.
• W3025317959 cites W2103812851 @default.
• W3025317959 cites W2116294933 @default.
• W3025317959 cites W2116461019 @default.
• W3025317959 cites W2120238028 @default.
• W3025317959 cites W2123794006 @default.
• W3025317959 cites W2127368722 @default.
• W3025317959 cites W2128597204 @default.
• W3025317959 cites W2129229339 @default.
• W3025317959 cites W2136132690 @default.
• W3025317959 cites W2142892008 @default.
• W3025317959 cites W2152156112 @default.
• W3025317959 cites W2155551728 @default.
• W3025317959 cites W2292586334 @default.
• W3025317959 cites W2326168530 @default.
• W3025317959 cites W2341550537 @default.
• W3025317959 cites W2343427124 @default.
• W3025317959 cites W2511716722 @default.
• W3025317959 cites W2542372902 @default.
• W3025317959 cites W2545267953 @default.
• W3025317959 cites W2619381843 @default.
• W3025317959 cites W2739773649 @default.
• W3025317959 cites W2751963214 @default.
• W3025317959 cites W2758403056 @default.
• W3025317959 cites W2761348774 @default.
• W3025317959 cites W2791030344 @default.
• W3025317959 cites W2796825733 @default.
• W3025317959 cites W2799499668 @default.
• W3025317959 cites W2894795516 @default.
• W3025317959 cites W2895290943 @default.
• W3025317959 cites W2902337882 @default.
• W3025317959 cites W2903897726 @default.
• W3025317959 cites W2905137679 @default.
• W3025317959 cites W2912407698 @default.
• W3025317959 cites W2933712812 @default.
• W3025317959 cites W2948384015 @default.
• W3025317959 cites W2981549418 @default.
• W3025317959 cites W2996580316 @default.
• W3025317959 cites W2996811954 @default.
• W3025317959 cites W4230641303 @default.
• W3025317959 cites W4300412324 @default.
• W3025317959 doi "https://doi.org/10.3389/fneur.2020.00415" @default.
• W3025317959 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7326092" @default.
• W3025317959 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32670175" @default.
• W3025317959 hasPublicationYear "2020" @default.
• W3025317959 type Work @default.
• W3025317959 sameAs 3025317959 @default.
• W3025317959 citedByCount "8" @default.
• W3025317959 countsByYear W30253179592021 @default.
• W3025317959 countsByYear W30253179592022 @default.
• W3025317959 countsByYear W30253179592023 @default.
• W3025317959 crossrefType "journal-article" @default.
• W3025317959 hasAuthorship W3025317959A5002804657 @default.
• W3025317959 hasAuthorship W3025317959A5013773031 @default.
• W3025317959 hasAuthorship W3025317959A5027452122 @default.
• W3025317959 hasAuthorship W3025317959A5053295756 @default.
• W3025317959 hasAuthorship W3025317959A5055451113 @default.
• W3025317959 hasAuthorship W3025317959A5060641186 @default.
• W3025317959 hasAuthorship W3025317959A5064745136 @default.
• W3025317959 hasAuthorship W3025317959A5075442778 @default.
• W3025317959 hasBestOaLocation W30253179591 @default.
• W3025317959 hasConcept C107130276 @default.
• W3025317959 hasConcept C118552586 @default.
• W3025317959 hasConcept C120665830 @default.
• W3025317959 hasConcept C121332964 @default.
• W3025317959 hasConcept C126322002 @default.
• W3025317959 hasConcept C187212893 @default.

• next