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- W3025320502 abstract "Understanding adaptive immunity to SARS-CoV-2 is important for vaccine development, interpreting coronavirus disease 2019 (COVID-19) pathogenesis, and calibration of pandemic control measures. Using HLA class I and II predicted peptide “megapools,” circulating SARS-CoV-2-specific CD8+ and CD4+ T cells were identified in ∼70% and 100% of COVID-19 convalescent patients, respectively. CD4+ T cell responses to spike, the main target of most vaccine efforts, were robust and correlated with the magnitude of the anti-SARS-CoV-2 IgG and IgA titers. The M, spike, and N proteins each accounted for 11%–27% of the total CD4+ response, with additional responses commonly targeting nsp3, nsp4, ORF3a, and ORF8, among others. For CD8+ T cells, spike and M were recognized, with at least eight SARS-CoV-2 ORFs targeted. Importantly, we detected SARS-CoV-2-reactive CD4+ T cells in ∼40%–60% of unexposed individuals, suggesting cross-reactive T cell recognition between circulating “common cold” coronaviruses and SARS-CoV-2." @default.
- W3025320502 created "2020-05-21" @default.
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- W3025320502 date "2020-06-01" @default.
- W3025320502 modified "2023-10-17" @default.
- W3025320502 title "Targets of T Cell Responses to SARS-CoV-2 Coronavirus in Humans with COVID-19 Disease and Unexposed Individuals" @default.
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- W3025320502 doi "https://doi.org/10.1016/j.cell.2020.05.015" @default.
- W3025320502 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7237901" @default.
- W3025320502 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32473127" @default.
- W3025320502 hasPublicationYear "2020" @default.