FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3025329443> ?p ?o ?g. }

• W3025329443 endingPage "9" @default.
• W3025329443 startingPage "51" @default.
• W3025329443 abstract "Stimulation of human neutrophils (PMN) with Ca ionophore A23187, opsonized zymosan and formyl-L-methionyl-L-leucyl-phenylalanine (FMLP) led to a time- and dose-dependent release of LTB4, 20-OH-LTB4, 20-COOH-LTB4, 6-trans-LTB4, 12-epi-6-trans LTB4 and LTC4, as detected by reverse-phase HPLC. Preincubation of the PMN suspension in the presence of Ca2+ and Mg2+ with phorbol-12-myristate-13-acetate (PMA) did not release leukotrienes by itself, but modulated the subsequent Ca ionophore-induced leukotriene release. The release of LTC4, 20-OH-LTB4 and 20-COOH-LTB4 was significantly decreased. Lesser effects were observed for the release of LTB4 and the non-enzymatic LTB4 isomers. In contrast, opsonized zymosan and FMLP enhanced the release of LTB4 and LTB4-omega-oxidation products from cells pretreated with PMA. With arachidonic acid as prestimulus, the amounts of the LTB4 isomers (6-trans-LTB4 and 12-epi-6-trans-LTB4) were enhanced significantly on subsequent stimulation with Ca ionophore. Prestimulation of lymphocytes, monocytes and basophilic granulocytes (LMB) with PMA had no significant effects on the ionophore-induced release of LTC4 and LTB4. PMN, but not LMB, suspensions prestimulated with PMA convert exogenously added LTC4 to LTB4 isomers and LTC4 sulphoxide. Our data suggest that preincubation of human granulocytes with PMA modified leukotriene release by activation or inhibition of different metabolic pathways for LTC4 and LTB4." @default.
• W3025329443 created "2020-05-21" @default.
• W3025329443 creator A5039986893 @default.
• W3025329443 creator A5048529897 @default.
• W3025329443 date "1988-05-01" @default.
• W3025329443 modified "2023-10-18" @default.
• W3025329443 title "Modulation of leukotriene release from human polymorphonuclear leucocytes by PMA and arachidonic acid." @default.
• W3025329443 cites W119836714 @default.
• W3025329443 cites W1486516901 @default.
• W3025329443 cites W1489769246 @default.
• W3025329443 cites W1505976169 @default.
• W3025329443 cites W151242301 @default.
• W3025329443 cites W1515427160 @default.
• W3025329443 cites W1552275448 @default.
• W3025329443 cites W1559121852 @default.
• W3025329443 cites W1589689744 @default.
• W3025329443 cites W1602520925 @default.
• W3025329443 cites W1972482295 @default.
• W3025329443 cites W1993632060 @default.
• W3025329443 cites W1999494984 @default.
• W3025329443 cites W2001692359 @default.
• W3025329443 cites W2016274621 @default.
• W3025329443 cites W2027704731 @default.
• W3025329443 cites W2028692741 @default.
• W3025329443 cites W2028868263 @default.
• W3025329443 cites W2036145275 @default.
• W3025329443 cites W2062986756 @default.
• W3025329443 cites W2068877244 @default.
• W3025329443 cites W2083611460 @default.
• W3025329443 cites W2088607434 @default.
• W3025329443 cites W2117462724 @default.
• W3025329443 cites W2141817909 @default.
• W3025329443 cites W2403137876 @default.
• W3025329443 cites W2419468357 @default.
• W3025329443 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1385185" @default.
• W3025329443 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2838420" @default.
• W3025329443 hasPublicationYear "1988" @default.
• W3025329443 type Work @default.
• W3025329443 sameAs 3025329443 @default.
• W3025329443 citedByCount "5" @default.
• W3025329443 countsByYear W30253294432016 @default.
• W3025329443 crossrefType "journal-article" @default.
• W3025329443 hasAuthorship W3025329443A5039986893 @default.
• W3025329443 hasAuthorship W3025329443A5048529897 @default.
• W3025329443 hasConcept C134018914 @default.
• W3025329443 hasConcept C178790620 @default.
• W3025329443 hasConcept C181199279 @default.
• W3025329443 hasConcept C185592680 @default.
• W3025329443 hasConcept C202751555 @default.
• W3025329443 hasConcept C203014093 @default.
• W3025329443 hasConcept C24998067 @default.
• W3025329443 hasConcept C2776042228 @default.
• W3025329443 hasConcept C2776452501 @default.
• W3025329443 hasConcept C2776685179 @default.
• W3025329443 hasConcept C2776914184 @default.
• W3025329443 hasConcept C2777983669 @default.
• W3025329443 hasConcept C2778078955 @default.
• W3025329443 hasConcept C2778870864 @default.
• W3025329443 hasConcept C2779014961 @default.
• W3025329443 hasConcept C2779543280 @default.
• W3025329443 hasConcept C41625074 @default.
• W3025329443 hasConcept C519063684 @default.
• W3025329443 hasConcept C55493867 @default.
• W3025329443 hasConcept C86803240 @default.
• W3025329443 hasConceptScore W3025329443C134018914 @default.
• W3025329443 hasConceptScore W3025329443C178790620 @default.
• W3025329443 hasConceptScore W3025329443C181199279 @default.
• W3025329443 hasConceptScore W3025329443C185592680 @default.
• W3025329443 hasConceptScore W3025329443C202751555 @default.
• W3025329443 hasConceptScore W3025329443C203014093 @default.
• W3025329443 hasConceptScore W3025329443C24998067 @default.
• W3025329443 hasConceptScore W3025329443C2776042228 @default.
• W3025329443 hasConceptScore W3025329443C2776452501 @default.
• W3025329443 hasConceptScore W3025329443C2776685179 @default.
• W3025329443 hasConceptScore W3025329443C2776914184 @default.
• W3025329443 hasConceptScore W3025329443C2777983669 @default.
• W3025329443 hasConceptScore W3025329443C2778078955 @default.
• W3025329443 hasConceptScore W3025329443C2778870864 @default.
• W3025329443 hasConceptScore W3025329443C2779014961 @default.
• W3025329443 hasConceptScore W3025329443C2779543280 @default.
• W3025329443 hasConceptScore W3025329443C41625074 @default.
• W3025329443 hasConceptScore W3025329443C519063684 @default.
• W3025329443 hasConceptScore W3025329443C55493867 @default.
• W3025329443 hasConceptScore W3025329443C86803240 @default.
• W3025329443 hasIssue "1" @default.
• W3025329443 hasLocation W30253294431 @default.
• W3025329443 hasOpenAccess W3025329443 @default.
• W3025329443 hasPrimaryLocation W30253294431 @default.
• W3025329443 hasRelatedWork W1674649357 @default.
• W3025329443 hasRelatedWork W1981347701 @default.
• W3025329443 hasRelatedWork W2014977968 @default.
• W3025329443 hasRelatedWork W2031269904 @default.
• W3025329443 hasRelatedWork W2064009996 @default.
• W3025329443 hasRelatedWork W2075616761 @default.
• W3025329443 hasRelatedWork W2087574089 @default.
• W3025329443 hasRelatedWork W2090227440 @default.
• W3025329443 hasRelatedWork W2419468357 @default.
• W3025329443 hasRelatedWork W3025329443 @default.

• next