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- W3025332376 abstract "Adipose tissue in physiological and in metabolically altered conditions (obesity, diabetes, metabolic syndrome) strictly interacts with the developing tumors both systemically and locally. In addition to the cancer-associated fibroblasts, adipose cells have also recently been described among the pivotal actors of the tumor microenvironment responsible for sustaining tumor development and progression. In particular, emerging evidence suggests that not only the mature adipocytes but also the adipose stem cells (ASCs) are able to establish a strict crosstalk with the tumour cells, thus resulting in a reciprocal reprogramming of both the tumor and adipose components. This review will focus on the metabolic changes induced by this interaction as a driver of fate determination occurring in cancer-associated ASCs (CA-ASCs) to support the tumor metabolic requirements. We will showcase the major role played by the metabolic changes occurring in the adipose tumor microenvironment that regulates ASC fate and consequently cancer progression. Our new results will also highlight the CA-ASC response in vitro by using a coculture system of primary ASCs grown with cancer cells originating from two different types of adrenal cancers [adrenocortical carcinoma (ACC) and pheochromocytoma]. In conclusion, the different factors involved in this crosstalk process will be analyzed and their effects on the adipocyte differentiation potential and functions of CA-ASCs will be discussed." @default.
- W3025332376 created "2020-05-21" @default.
- W3025332376 creator A5016806501 @default.
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- W3025332376 date "2020-05-15" @default.
- W3025332376 modified "2023-10-13" @default.
- W3025332376 title "The Role of Metabolic Changes in Shaping the Fate of Cancer-Associated Adipose Stem Cells" @default.
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- W3025332376 doi "https://doi.org/10.3389/fcell.2020.00332" @default.
- W3025332376 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7242628" @default.
- W3025332376 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32478073" @default.
- W3025332376 hasPublicationYear "2020" @default.
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