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- W3025340685 endingPage "212" @default.
- W3025340685 startingPage "197" @default.
- W3025340685 abstract "Abstract The eukaryotic endomembrane system plays a key role in responses of cells to stress and maintains cell homeostasis in health and disease. Its two components, exosome biogenesis and autophagy are linked through the shared molecular machinery in the endolysosomal pathway. The distinction between exosomes derived from the endosome and extracellular vesicles (EVs) produced by secretory autophagy is difficult, because of molecular crosstalk existing between the exosome and autophagy pathways. Dichotomous effects these EVs mediate in health and disease suggest they comprise vesicles derived from both pathways. The crosstalk between these pathways provides the host immune cells with context-dependent signals that might differentially drive innate and adaptive immune responses. The messages carried by autophagy-derived EVs may be distinct from messages exosomes deliver to immune cells and might induce immune responses that are qualitatively and quantitatively different. The presence of exosome biogenesis and autophagy might allow for the calibration of immune responses under various environmental stress conditions. This hypothesis is an attempt to explain why autophagy and exosome biogenesis exist as distinct albeit interactive and partially overlapping cellular pathways. By simultaneously engaging the host immune system, exosomes and autophagy maintain the balance required for cellular homeostasis under physiological and pathological conditions." @default.
- W3025340685 created "2020-05-21" @default.
- W3025340685 creator A5050172772 @default.
- W3025340685 creator A5071077060 @default.
- W3025340685 date "2020-01-01" @default.
- W3025340685 modified "2023-10-16" @default.
- W3025340685 title "Interplay between exosomes and autophagy: Are they partners in crime?" @default.
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- W3025340685 doi "https://doi.org/10.1016/b978-0-12-819609-0.00011-0" @default.