FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3025347528> ?p ?o ?g. }

• W3025347528 abstract "Abstract Problem Late in pregnancy, women produce and transfer high amounts of antibodies to the foetus. During gestation, women produce antibodies against human leukocyte antigens (HLA), including antibodies directed at foetal HLA. There is paucity of data on transplacental crossing, specificity and role of HLA antibodies in pregnancy and new‐borns. Method of study Using highly sensitive Luminex technology, we measured prevalence of IgG HLA antibodies in 30 mother‐infant pairs six weeks post‐partum. Additionally, in six pregnant women, we measured HLA antibodies longitudinally and HLA‐typed infant DNA to assess whether maternal HLA antibodies were directed at infant specificities. Results Overall, 68% of mothers and 44% of infants expressed HLA‐I antibodies and 56% of mothers and 52% of infants expressed HLA‐II antibodies. Infants shared up to 78% of antibodies with their mothers, suggesting that the remaining antibodies were self‐made. Less than 25% of maternal HLA antibodies were detected in infants, possibly due to selection in transplacental crossing. We detected complement‐fixing HLA antibodies in mothers and at low levels in infants. In a third of our pregnant subjects, we detected infant‐directed HLA antibodies. Conclusion Our findings raise the possibility of selection in transplacental crossing of HLA antibodies. As HLA antibodies may act as autoantibodies in the neonate, the mechanism of a selective transfer may give important insights into immune tolerance. Findings also suggest that infants start producing their own HLA antibodies in the first weeks of life, which, together with maternally derived antibodies may impact the infant's immune reaction to HLA proteins." @default.
• W3025347528 created "2020-05-21" @default.
• W3025347528 creator A5000966371 @default.
• W3025347528 creator A5025028740 @default.
• W3025347528 creator A5033213833 @default.
• W3025347528 creator A5037547301 @default.
• W3025347528 creator A5040353865 @default.
• W3025347528 creator A5048504899 @default.
• W3025347528 creator A5068041641 @default.
• W3025347528 creator A5078342778 @default.
• W3025347528 creator A5083083927 @default.
• W3025347528 creator A5083098540 @default.
• W3025347528 date "2020-06-16" @default.
• W3025347528 modified "2023-10-18" @default.
• W3025347528 title "HLA antibody repertoire in infants suggests selectivity in transplacental crossing" @default.
• W3025347528 cites W1562748442 @default.
• W3025347528 cites W1905230553 @default.
• W3025347528 cites W1949224245 @default.
• W3025347528 cites W1964565222 @default.
• W3025347528 cites W1972226169 @default.
• W3025347528 cites W1973976214 @default.
• W3025347528 cites W1989206432 @default.
• W3025347528 cites W1989816585 @default.
• W3025347528 cites W1991355715 @default.
• W3025347528 cites W1993278936 @default.
• W3025347528 cites W2015127103 @default.
• W3025347528 cites W2023610511 @default.
• W3025347528 cites W2026562883 @default.
• W3025347528 cites W2033397780 @default.
• W3025347528 cites W2038252281 @default.
• W3025347528 cites W2038805518 @default.
• W3025347528 cites W2039557940 @default.
• W3025347528 cites W2042298936 @default.
• W3025347528 cites W2046895858 @default.
• W3025347528 cites W2046977181 @default.
• W3025347528 cites W2047019431 @default.
• W3025347528 cites W2047224721 @default.
• W3025347528 cites W2050962164 @default.
• W3025347528 cites W2059612196 @default.
• W3025347528 cites W2060246599 @default.
• W3025347528 cites W2064085330 @default.
• W3025347528 cites W2064188087 @default.
• W3025347528 cites W2071843728 @default.
• W3025347528 cites W2086289355 @default.
• W3025347528 cites W2087156294 @default.
• W3025347528 cites W2093332691 @default.
• W3025347528 cites W2093336544 @default.
• W3025347528 cites W2096035536 @default.
• W3025347528 cites W2096591517 @default.
• W3025347528 cites W2097036731 @default.
• W3025347528 cites W2099018318 @default.
• W3025347528 cites W2103326273 @default.
• W3025347528 cites W2115657669 @default.
• W3025347528 cites W2117737461 @default.
• W3025347528 cites W2120031697 @default.
• W3025347528 cites W2124217818 @default.
• W3025347528 cites W2134190966 @default.
• W3025347528 cites W2145666776 @default.
• W3025347528 cites W2149493095 @default.
• W3025347528 cites W2156287773 @default.
• W3025347528 cites W2158109619 @default.
• W3025347528 cites W2172224306 @default.
• W3025347528 cites W2215196112 @default.
• W3025347528 cites W2233660390 @default.
• W3025347528 cites W2252378111 @default.
• W3025347528 cites W2299193714 @default.
• W3025347528 cites W2303470476 @default.
• W3025347528 cites W2554238630 @default.
• W3025347528 cites W2560747148 @default.
• W3025347528 cites W2572383121 @default.
• W3025347528 cites W2586513851 @default.
• W3025347528 cites W2602023503 @default.
• W3025347528 cites W2606115039 @default.
• W3025347528 cites W2663964154 @default.
• W3025347528 cites W2763828682 @default.
• W3025347528 cites W2809727071 @default.
• W3025347528 cites W2888423166 @default.
• W3025347528 cites W2950487229 @default.
• W3025347528 cites W2950802088 @default.
• W3025347528 cites W4246562399 @default.
• W3025347528 cites W4313342421 @default.
• W3025347528 doi "https://doi.org/10.1111/aji.13264" @default.
• W3025347528 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7507134" @default.
• W3025347528 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32395838" @default.
• W3025347528 hasPublicationYear "2020" @default.
• W3025347528 type Work @default.
• W3025347528 sameAs 3025347528 @default.
• W3025347528 citedByCount "3" @default.
• W3025347528 countsByYear W30253475282022 @default.
• W3025347528 countsByYear W30253475282023 @default.
• W3025347528 crossrefType "journal-article" @default.
• W3025347528 hasAuthorship W3025347528A5000966371 @default.
• W3025347528 hasAuthorship W3025347528A5025028740 @default.
• W3025347528 hasAuthorship W3025347528A5033213833 @default.
• W3025347528 hasAuthorship W3025347528A5037547301 @default.
• W3025347528 hasAuthorship W3025347528A5040353865 @default.
• W3025347528 hasAuthorship W3025347528A5048504899 @default.
• W3025347528 hasAuthorship W3025347528A5068041641 @default.
• W3025347528 hasAuthorship W3025347528A5078342778 @default.
• W3025347528 hasAuthorship W3025347528A5083083927 @default.

• next