Matches in SemOpenAlex for { <https://semopenalex.org/work/W3025370650> ?p ?o ?g. }
- W3025370650 endingPage "1232" @default.
- W3025370650 startingPage "1232" @default.
- W3025370650 abstract "Osteoarthritis (OA) is a disease associated to age or conditions that precipitate aging of articular cartilage, a post-mitotic tissue that remains functional until the failure of major homeostatic mechanisms. OA severely impacts the national health system costs and patients’ quality of life because of pain and disability. It is a whole-joint disease sustained by inflammatory and oxidative signaling pathways and marked epigenetic changes responsible for catabolism of the cartilage extracellular matrix. OA usually progresses until its severity requires joint arthroplasty. To delay this progression and to improve symptoms, a wide range of naturally derived compounds have been proposed and are summarized in this review. Preclinical in vitro and in vivo studies have provided proof of principle that many of these nutraceuticals are able to exert pleiotropic and synergistic effects and effectively counteract OA pathogenesis by exerting both anti-inflammatory and antioxidant activities and by tuning major OA-related signaling pathways. The latter are the basis for the nutrigenomic role played by some of these compounds, given the marked changes in the transcriptome, miRNome, and methylome. Ongoing and future clinical trials will hopefully confirm the disease-modifying ability of these bioactive molecules in OA patients." @default.
- W3025370650 created "2020-05-21" @default.
- W3025370650 creator A5036820714 @default.
- W3025370650 creator A5042339894 @default.
- W3025370650 creator A5051779028 @default.
- W3025370650 creator A5072167771 @default.
- W3025370650 creator A5085849816 @default.
- W3025370650 creator A5091076723 @default.
- W3025370650 date "2020-05-16" @default.
- W3025370650 modified "2023-10-16" @default.
- W3025370650 title "Nutraceutical Activity in Osteoarthritis Biology: A Focus on the Nutrigenomic Role" @default.
- W3025370650 cites W1273386794 @default.
- W3025370650 cites W1496082710 @default.
- W3025370650 cites W1534012180 @default.
- W3025370650 cites W1574550065 @default.
- W3025370650 cites W1592178673 @default.
- W3025370650 cites W1631176140 @default.
- W3025370650 cites W1696260634 @default.
- W3025370650 cites W1795358129 @default.
- W3025370650 cites W1854307882 @default.
- W3025370650 cites W1966766447 @default.
- W3025370650 cites W1967495700 @default.
- W3025370650 cites W1968097552 @default.
- W3025370650 cites W1969224465 @default.
- W3025370650 cites W1969721611 @default.
- W3025370650 cites W1972117948 @default.
- W3025370650 cites W1973698276 @default.
- W3025370650 cites W1973788312 @default.
- W3025370650 cites W1977879381 @default.
- W3025370650 cites W1979653063 @default.
- W3025370650 cites W1983329739 @default.
- W3025370650 cites W1983937216 @default.
- W3025370650 cites W1985004392 @default.
- W3025370650 cites W1988339898 @default.
- W3025370650 cites W1992532731 @default.
- W3025370650 cites W1994091658 @default.
- W3025370650 cites W1995860725 @default.
- W3025370650 cites W2002251686 @default.
- W3025370650 cites W2005008958 @default.
- W3025370650 cites W2009827516 @default.
- W3025370650 cites W2011928284 @default.
- W3025370650 cites W2013758779 @default.
- W3025370650 cites W2014140858 @default.
- W3025370650 cites W2014935606 @default.
- W3025370650 cites W2020193971 @default.
- W3025370650 cites W2023298835 @default.
- W3025370650 cites W2027831505 @default.
- W3025370650 cites W2029285402 @default.
- W3025370650 cites W2030373321 @default.
- W3025370650 cites W2030628560 @default.
- W3025370650 cites W2031361940 @default.
- W3025370650 cites W2031690762 @default.
- W3025370650 cites W2040155058 @default.
- W3025370650 cites W2043612827 @default.
- W3025370650 cites W2049946991 @default.
- W3025370650 cites W2051489319 @default.
- W3025370650 cites W2055340082 @default.
- W3025370650 cites W2063210598 @default.
- W3025370650 cites W2064698132 @default.
- W3025370650 cites W2067694345 @default.
- W3025370650 cites W2070137023 @default.
- W3025370650 cites W2070789464 @default.
- W3025370650 cites W2077723599 @default.
- W3025370650 cites W2083740873 @default.
- W3025370650 cites W2085294880 @default.
- W3025370650 cites W2086798367 @default.
- W3025370650 cites W2087598895 @default.
- W3025370650 cites W2087958138 @default.
- W3025370650 cites W2088394403 @default.
- W3025370650 cites W2088657142 @default.
- W3025370650 cites W2089070118 @default.
- W3025370650 cites W2089605568 @default.
- W3025370650 cites W2090113481 @default.
- W3025370650 cites W2095221899 @default.
- W3025370650 cites W2095835247 @default.
- W3025370650 cites W2106298197 @default.
- W3025370650 cites W2108273756 @default.
- W3025370650 cites W2109299850 @default.
- W3025370650 cites W2114057457 @default.
- W3025370650 cites W2114090595 @default.
- W3025370650 cites W2118089705 @default.
- W3025370650 cites W2118944124 @default.
- W3025370650 cites W2124111734 @default.
- W3025370650 cites W2127819448 @default.
- W3025370650 cites W2128378130 @default.
- W3025370650 cites W2130086746 @default.
- W3025370650 cites W2132413890 @default.
- W3025370650 cites W2132612143 @default.
- W3025370650 cites W2151089147 @default.
- W3025370650 cites W2155671648 @default.
- W3025370650 cites W2159914115 @default.
- W3025370650 cites W2169999439 @default.
- W3025370650 cites W2209192783 @default.
- W3025370650 cites W2279898688 @default.
- W3025370650 cites W2300873705 @default.
- W3025370650 cites W2336790340 @default.
- W3025370650 cites W2337323913 @default.
- W3025370650 cites W2339323293 @default.