Matches in SemOpenAlex for { <https://semopenalex.org/work/W3025428623> ?p ?o ?g. }
- W3025428623 endingPage "1463" @default.
- W3025428623 startingPage "1463" @default.
- W3025428623 abstract "Acute pancreatitis (AP) may be associated with severe inflammation and hypovolemia leading to organ complications including acute kidney injury (AKI). According to current guidelines, AKI diagnosis is based on dynamic increase in serum creatinine, however, creatinine increase may be influenced by nonrenal factor and appears late following kidney injury. Kidney injury molecule-1 (KIM-1) is a promising marker of renal tubular injury and it has not been studied in AP. Our aim was to assess if urinary KIM-1 may be used to diagnose AKI complicating the early stage of AP. We recruited 69 patients with mild to severe AP admitted to a secondary care hospital during the first 24 h from initial symptoms of AP. KIM-1 was measured in urine samples collected on the day of admission and two subsequent days of hospital stay. AKI was diagnosed based on creatinine increase according to Kidney Disease: Improving Global Outcomes 2012 guidelines. Urinary KIM-1 on study days 1 to 3 was not significantly higher in 10 patients who developed AKI as compared to those without AKI and did not correlate with serum creatinine or urea. On days 2 and 3, urinary KIM-1 correlated positively with urinary liver-type fatty acid-binding protein, another marker of tubular injury. On days 2 and 3, urinary KIM-1 was higher among patients with systemic inflammatory response syndrome, and several correlations between KIM-1 and inflammatory markers (procalcitonin, urokinase-type plasminogen activator receptor, C-reactive protein) were observed on days 1 to 3. With a limited number of patients, our study cannot exclude the diagnostic utility of KIM-1 in AP, however, our results do not support it. We hypothesize that the increase of KIM-1 in AKI complicating AP lasts a short time, and it may only be observed with more frequent monitoring of the marker. Moreover, urinary KIM-1 concentrations in AP are associated with inflammation severity." @default.
- W3025428623 created "2020-05-21" @default.
- W3025428623 creator A5013422717 @default.
- W3025428623 creator A5026905220 @default.
- W3025428623 creator A5027159153 @default.
- W3025428623 creator A5045766085 @default.
- W3025428623 creator A5079286037 @default.
- W3025428623 creator A5080635709 @default.
- W3025428623 creator A5084847881 @default.
- W3025428623 creator A5089627000 @default.
- W3025428623 date "2020-05-13" @default.
- W3025428623 modified "2023-10-10" @default.
- W3025428623 title "The Marker of Tubular Injury, Kidney Injury Molecule-1 (KIM-1), in Acute Kidney Injury Complicating Acute Pancreatitis: A Preliminary Study" @default.
- W3025428623 cites W1499722362 @default.
- W3025428623 cites W1516311606 @default.
- W3025428623 cites W1964405385 @default.
- W3025428623 cites W1967157788 @default.
- W3025428623 cites W1974387984 @default.
- W3025428623 cites W1997758474 @default.
- W3025428623 cites W2003500862 @default.
- W3025428623 cites W2006234287 @default.
- W3025428623 cites W2015741867 @default.
- W3025428623 cites W2025627399 @default.
- W3025428623 cites W2039499065 @default.
- W3025428623 cites W2059594773 @default.
- W3025428623 cites W2061536430 @default.
- W3025428623 cites W2065582745 @default.
- W3025428623 cites W2075017854 @default.
- W3025428623 cites W2081141743 @default.
- W3025428623 cites W2090711013 @default.
- W3025428623 cites W2099716924 @default.
- W3025428623 cites W2101237274 @default.
- W3025428623 cites W2135864573 @default.
- W3025428623 cites W2145758369 @default.
- W3025428623 cites W2164469730 @default.
- W3025428623 cites W2271842806 @default.
- W3025428623 cites W2292349136 @default.
- W3025428623 cites W2320835511 @default.
- W3025428623 cites W2326184692 @default.
- W3025428623 cites W2336291004 @default.
- W3025428623 cites W2499459691 @default.
- W3025428623 cites W2511806627 @default.
- W3025428623 cites W2516526482 @default.
- W3025428623 cites W2522690635 @default.
- W3025428623 cites W2534542788 @default.
- W3025428623 cites W2581605534 @default.
- W3025428623 cites W2587422283 @default.
- W3025428623 cites W2587808121 @default.
- W3025428623 cites W2743576537 @default.
- W3025428623 cites W2747824807 @default.
- W3025428623 cites W2764303225 @default.
- W3025428623 cites W2805751882 @default.
- W3025428623 cites W2892241843 @default.
- W3025428623 cites W2895946319 @default.
- W3025428623 cites W2900505374 @default.
- W3025428623 cites W2907203063 @default.
- W3025428623 cites W2921087720 @default.
- W3025428623 cites W2945190478 @default.
- W3025428623 cites W2958721811 @default.
- W3025428623 cites W2965814019 @default.
- W3025428623 cites W2980813958 @default.
- W3025428623 cites W2998870726 @default.
- W3025428623 cites W376987419 @default.
- W3025428623 cites W4211022384 @default.
- W3025428623 cites W63176095 @default.
- W3025428623 cites W974014543 @default.
- W3025428623 doi "https://doi.org/10.3390/jcm9051463" @default.
- W3025428623 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7290845" @default.
- W3025428623 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32414176" @default.
- W3025428623 hasPublicationYear "2020" @default.
- W3025428623 type Work @default.
- W3025428623 sameAs 3025428623 @default.
- W3025428623 citedByCount "7" @default.
- W3025428623 countsByYear W30254286232020 @default.
- W3025428623 countsByYear W30254286232021 @default.
- W3025428623 countsByYear W30254286232022 @default.
- W3025428623 countsByYear W30254286232023 @default.
- W3025428623 crossrefType "journal-article" @default.
- W3025428623 hasAuthorship W3025428623A5013422717 @default.
- W3025428623 hasAuthorship W3025428623A5026905220 @default.
- W3025428623 hasAuthorship W3025428623A5027159153 @default.
- W3025428623 hasAuthorship W3025428623A5045766085 @default.
- W3025428623 hasAuthorship W3025428623A5079286037 @default.
- W3025428623 hasAuthorship W3025428623A5080635709 @default.
- W3025428623 hasAuthorship W3025428623A5084847881 @default.
- W3025428623 hasAuthorship W3025428623A5089627000 @default.
- W3025428623 hasBestOaLocation W30254286231 @default.
- W3025428623 hasConcept C10936531 @default.
- W3025428623 hasConcept C126322002 @default.
- W3025428623 hasConcept C126894567 @default.
- W3025428623 hasConcept C2776670229 @default.
- W3025428623 hasConcept C2778384902 @default.
- W3025428623 hasConcept C2778653478 @default.
- W3025428623 hasConcept C2780306776 @default.
- W3025428623 hasConcept C2780472472 @default.
- W3025428623 hasConcept C2781309813 @default.
- W3025428623 hasConcept C71924100 @default.
- W3025428623 hasConcept C77411442 @default.