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- W3025431657 abstract "Ten-eleven Translocation (TET) proteins have emerged as a family of epigenetic regulators that are important during development and have been implicated in various types of cancers. TET is a highly conserved protein that has orthologues in almost all multicellular organisms. Here, we review recent literature on the novel substrate specificity of this family of DNA 5-methylcytosine demethylases on DNA 6-methyladenine and RNA 5-methylcytosine that were first identified in the invertebrate model Drosophila. We focus on the biological role of these novel epigenetic marks in the fruit fly and mammals and highlight TET proteins’ critical function during development specifically in brain development." @default.
- W3025431657 created "2020-05-21" @default.
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- W3025431657 date "2020-05-18" @default.
- W3025431657 modified "2023-10-01" @default.
- W3025431657 title "Ten-eleven translocation proteins and their role beyond DNA demethylation – what we can learn from the fly" @default.
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- W3025431657 doi "https://doi.org/10.1080/15592294.2020.1767323" @default.
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