Matches in SemOpenAlex for { <https://semopenalex.org/work/W3025445002> ?p ?o ?g. }
Showing items 1 to 83 of
83
with 100 items per page.
- W3025445002 endingPage "2091" @default.
- W3025445002 startingPage "2085" @default.
- W3025445002 abstract "In the study, we developed a novel formulation, CD123 mono-antibody (mAb) modified tanshinone ⅡA loaded immunoliposome (CD123-TanⅡA-ILP) to achieve the targeted drug delivery for leukemia cells. Orthogonal test was used to optimize liposome preparation, and the TanⅡA-loaded PEGylated liposomes (TanⅡA-LP) of S100PC-Chol-(mPEG2000-DSPE)-TanⅡA at 19∶5∶1∶1 molar ratio were prepared by the thin film hydration-probe ultrasonic method. A post-insertion method was applied to prepare CD123-TanⅡA-ILP via thiolated mAb conjugated to the terminal of maleimide-PEG2000-DSPE. The cellular uptake assay was measured by flow cytometry, and the inhibitory effect of CD123-TanⅡA-ILP on NB4 cells proliferation was tested by using MTT assay. The results of cellular uptake assay showed that CD123-ILP could significantly increase the drug uptake of NB4 cells as compared with free drugs and LP. The IC₅₀ values at 48 h incubation were 20.87, 11.71, 7.17 μmol•L⁻¹ respectively for TanⅡA，TanⅡA-LP and CD123-TanⅡA-ILP. CD123-ILP demonstrated a potential and promising targeted drug delivery strategy for acute myelogenous leukemia (AML) treatment." @default.
- W3025445002 created "2020-05-21" @default.
- W3025445002 creator A5040205037 @default.
- W3025445002 creator A5057454191 @default.
- W3025445002 creator A5060976698 @default.
- W3025445002 creator A5062194964 @default.
- W3025445002 creator A5063253432 @default.
- W3025445002 creator A5072923922 @default.
- W3025445002 creator A5085518003 @default.
- W3025445002 date "2017-06-01" @default.
- W3025445002 modified "2023-09-26" @default.
- W3025445002 title "[Preparation of CD123 mono-antibody modified tanshinone ⅡA loaded immunoliposome and its in vitro evaluation]." @default.
- W3025445002 doi "https://doi.org/10.19540/j.cnki.cjcmm.20170428.002" @default.
- W3025445002 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28822152" @default.
- W3025445002 hasPublicationYear "2017" @default.
- W3025445002 type Work @default.
- W3025445002 sameAs 3025445002 @default.
- W3025445002 citedByCount "0" @default.
- W3025445002 crossrefType "journal-article" @default.
- W3025445002 hasAuthorship W3025445002A5040205037 @default.
- W3025445002 hasAuthorship W3025445002A5057454191 @default.
- W3025445002 hasAuthorship W3025445002A5060976698 @default.
- W3025445002 hasAuthorship W3025445002A5062194964 @default.
- W3025445002 hasAuthorship W3025445002A5063253432 @default.
- W3025445002 hasAuthorship W3025445002A5072923922 @default.
- W3025445002 hasAuthorship W3025445002A5085518003 @default.
- W3025445002 hasConcept C10138342 @default.
- W3025445002 hasConcept C153911025 @default.
- W3025445002 hasConcept C159654299 @default.
- W3025445002 hasConcept C162324750 @default.
- W3025445002 hasConcept C178790620 @default.
- W3025445002 hasConcept C185154212 @default.
- W3025445002 hasConcept C185592680 @default.
- W3025445002 hasConcept C202751555 @default.
- W3025445002 hasConcept C203014093 @default.
- W3025445002 hasConcept C2779820397 @default.
- W3025445002 hasConcept C542903549 @default.
- W3025445002 hasConcept C54400483 @default.
- W3025445002 hasConcept C553184892 @default.
- W3025445002 hasConcept C55493867 @default.
- W3025445002 hasConcept C71924100 @default.
- W3025445002 hasConcept C83396363 @default.
- W3025445002 hasConcept C86803240 @default.
- W3025445002 hasConcept C98274493 @default.
- W3025445002 hasConceptScore W3025445002C10138342 @default.
- W3025445002 hasConceptScore W3025445002C153911025 @default.
- W3025445002 hasConceptScore W3025445002C159654299 @default.
- W3025445002 hasConceptScore W3025445002C162324750 @default.
- W3025445002 hasConceptScore W3025445002C178790620 @default.
- W3025445002 hasConceptScore W3025445002C185154212 @default.
- W3025445002 hasConceptScore W3025445002C185592680 @default.
- W3025445002 hasConceptScore W3025445002C202751555 @default.
- W3025445002 hasConceptScore W3025445002C203014093 @default.
- W3025445002 hasConceptScore W3025445002C2779820397 @default.
- W3025445002 hasConceptScore W3025445002C542903549 @default.
- W3025445002 hasConceptScore W3025445002C54400483 @default.
- W3025445002 hasConceptScore W3025445002C553184892 @default.
- W3025445002 hasConceptScore W3025445002C55493867 @default.
- W3025445002 hasConceptScore W3025445002C71924100 @default.
- W3025445002 hasConceptScore W3025445002C83396363 @default.
- W3025445002 hasConceptScore W3025445002C86803240 @default.
- W3025445002 hasConceptScore W3025445002C98274493 @default.
- W3025445002 hasIssue "11" @default.
- W3025445002 hasLocation W30254450021 @default.
- W3025445002 hasOpenAccess W3025445002 @default.
- W3025445002 hasPrimaryLocation W30254450021 @default.
- W3025445002 hasRelatedWork W2035990435 @default.
- W3025445002 hasRelatedWork W2193145023 @default.
- W3025445002 hasRelatedWork W2196101296 @default.
- W3025445002 hasRelatedWork W2381360239 @default.
- W3025445002 hasRelatedWork W2382797166 @default.
- W3025445002 hasRelatedWork W2410111069 @default.
- W3025445002 hasRelatedWork W2586973201 @default.
- W3025445002 hasRelatedWork W2745599793 @default.
- W3025445002 hasRelatedWork W2952175061 @default.
- W3025445002 hasRelatedWork W3006580768 @default.
- W3025445002 hasVolume "42" @default.
- W3025445002 isParatext "false" @default.
- W3025445002 isRetracted "false" @default.
- W3025445002 magId "3025445002" @default.
- W3025445002 workType "article" @default.