Matches in SemOpenAlex for { <https://semopenalex.org/work/W3025455923> ?p ?o ?g. }
Showing items 1 to 94 of
94
with 100 items per page.
- W3025455923 endingPage "147032032092397" @default.
- W3025455923 startingPage "147032032092397" @default.
- W3025455923 abstract "The angiotensin converting enzyme inhibitor ramipril is a standard antihypertensive therapy for many patients. Because angiotensin II may promote inflammation, we were interested in whether basal pretreatment with ramipril may modify renal function and inflammation as well as systemic outcome in experimentally induced sepsis in mice.Ramipril (10 mg/kg/day) pretreatment or placebo (NaCl) was given intraperitoneally for 5 days to C57BL6/J mice, followed by either sham operation or cecal ligation and puncture sepsis induction. Real-time polymerase chain reaction and immunological stains were used to evaluate renal gene and protein expression, respectively. Plasma creatinine, neutrophil-gelatinase associated lipocalin, and blood urea nitrogen were used as markers for renal function. A clinical severity score was determined.Administration of ramipril before cecal ligation and puncture surgery was associated with reduced renal inflammation but did not improved renal function and structure and even worsened the clinical status of septic mice.The data suggest that the effects of ramipril pretreatment are complex. Additional studies including monitoring of hemodynamic parameters are necessary to elucidate the exact mechanism(s) of this observation. In addition, the timing of the ramipril administration could be of importance." @default.
- W3025455923 created "2020-05-21" @default.
- W3025455923 creator A5017630574 @default.
- W3025455923 creator A5025075333 @default.
- W3025455923 creator A5053286329 @default.
- W3025455923 creator A5070005567 @default.
- W3025455923 date "2020-04-01" @default.
- W3025455923 modified "2023-09-29" @default.
- W3025455923 title "Ramipril pretreatment worsened renal injury and survival despite a reduction in renal inflammation in experimentally induced sepsis in mice" @default.
- W3025455923 cites W1751629383 @default.
- W3025455923 cites W1963975982 @default.
- W3025455923 cites W1992995831 @default.
- W3025455923 cites W2015213851 @default.
- W3025455923 cites W2023945291 @default.
- W3025455923 cites W2026538961 @default.
- W3025455923 cites W2070228025 @default.
- W3025455923 cites W2086256384 @default.
- W3025455923 cites W2091309724 @default.
- W3025455923 cites W2097805169 @default.
- W3025455923 cites W2107277218 @default.
- W3025455923 cites W2114193904 @default.
- W3025455923 cites W2167433809 @default.
- W3025455923 cites W2192080449 @default.
- W3025455923 cites W2319894206 @default.
- W3025455923 cites W2620241325 @default.
- W3025455923 cites W2735267565 @default.
- W3025455923 cites W2796204687 @default.
- W3025455923 cites W2894807585 @default.
- W3025455923 cites W2899910282 @default.
- W3025455923 cites W2912388172 @default.
- W3025455923 cites W2945495989 @default.
- W3025455923 doi "https://doi.org/10.1177/1470320320923977" @default.
- W3025455923 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7232051" @default.
- W3025455923 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32419571" @default.
- W3025455923 hasPublicationYear "2020" @default.
- W3025455923 type Work @default.
- W3025455923 sameAs 3025455923 @default.
- W3025455923 citedByCount "2" @default.
- W3025455923 countsByYear W30254559232021 @default.
- W3025455923 countsByYear W30254559232022 @default.
- W3025455923 crossrefType "journal-article" @default.
- W3025455923 hasAuthorship W3025455923A5017630574 @default.
- W3025455923 hasAuthorship W3025455923A5025075333 @default.
- W3025455923 hasAuthorship W3025455923A5053286329 @default.
- W3025455923 hasAuthorship W3025455923A5070005567 @default.
- W3025455923 hasBestOaLocation W30254559231 @default.
- W3025455923 hasConcept C126322002 @default.
- W3025455923 hasConcept C126894567 @default.
- W3025455923 hasConcept C159641895 @default.
- W3025455923 hasConcept C2776914184 @default.
- W3025455923 hasConcept C2778176769 @default.
- W3025455923 hasConcept C2778384902 @default.
- W3025455923 hasConcept C2779888176 @default.
- W3025455923 hasConcept C2780091579 @default.
- W3025455923 hasConcept C2780306776 @default.
- W3025455923 hasConcept C71924100 @default.
- W3025455923 hasConcept C84393581 @default.
- W3025455923 hasConcept C98274493 @default.
- W3025455923 hasConceptScore W3025455923C126322002 @default.
- W3025455923 hasConceptScore W3025455923C126894567 @default.
- W3025455923 hasConceptScore W3025455923C159641895 @default.
- W3025455923 hasConceptScore W3025455923C2776914184 @default.
- W3025455923 hasConceptScore W3025455923C2778176769 @default.
- W3025455923 hasConceptScore W3025455923C2778384902 @default.
- W3025455923 hasConceptScore W3025455923C2779888176 @default.
- W3025455923 hasConceptScore W3025455923C2780091579 @default.
- W3025455923 hasConceptScore W3025455923C2780306776 @default.
- W3025455923 hasConceptScore W3025455923C71924100 @default.
- W3025455923 hasConceptScore W3025455923C84393581 @default.
- W3025455923 hasConceptScore W3025455923C98274493 @default.
- W3025455923 hasIssue "2" @default.
- W3025455923 hasLocation W30254559231 @default.
- W3025455923 hasLocation W30254559232 @default.
- W3025455923 hasLocation W30254559233 @default.
- W3025455923 hasLocation W30254559234 @default.
- W3025455923 hasOpenAccess W3025455923 @default.
- W3025455923 hasPrimaryLocation W30254559231 @default.
- W3025455923 hasRelatedWork W2062717800 @default.
- W3025455923 hasRelatedWork W2063107464 @default.
- W3025455923 hasRelatedWork W2095214324 @default.
- W3025455923 hasRelatedWork W2349987816 @default.
- W3025455923 hasRelatedWork W2353806027 @default.
- W3025455923 hasRelatedWork W2371369831 @default.
- W3025455923 hasRelatedWork W2377006731 @default.
- W3025455923 hasRelatedWork W2377952855 @default.
- W3025455923 hasRelatedWork W3117361317 @default.
- W3025455923 hasRelatedWork W656697013 @default.
- W3025455923 hasVolume "21" @default.
- W3025455923 isParatext "false" @default.
- W3025455923 isRetracted "false" @default.
- W3025455923 magId "3025455923" @default.
- W3025455923 workType "article" @default.