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- W3025494611 abstract "Alveolar formation increases the surface area for gas-exchange and is key to the physiological function of the lung. Alveolar epithelial cells, myofibroblasts and endothelial cells undergo coordinated morphogenesis to generate epithelial folds (secondary septa) to form alveoli. A mechanistic understanding of alveologenesis remains incomplete. We found that the planar cell polarity (PCP) pathway is required in alveolar epithelial cells and myofibroblasts for alveologenesis in mammals. Our studies uncovered a Wnt5a–Ror2–Vangl2 cascade that endows cellular properties and novel mechanisms of alveologenesis. This includes PDGF secretion from alveolar type I and type II cells, cell shape changes of type I cells and migration of myofibroblasts. All these cellular properties are conferred by changes in the cytoskeleton and represent a new facet of PCP function. These results extend our current model of PCP signaling from polarizing a field of epithelial cells to conferring new properties at subcellular levels to regulate collective cell behavior." @default.
- W3025494611 created "2020-05-21" @default.
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- W3025494611 date "2020-05-12" @default.
- W3025494611 modified "2023-10-13" @default.
- W3025494611 title "A mammalian Wnt5a–Ror2–Vangl2 axis controls the cytoskeleton and confers cellular properties required for alveologenesis" @default.
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- W3025494611 doi "https://doi.org/10.7554/elife.53688" @default.
- W3025494611 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7217702" @default.
- W3025494611 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32394892" @default.
- W3025494611 hasPublicationYear "2020" @default.
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