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- W3025519056 endingPage "121" @default.
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- W3025519056 abstract "Shigellosis, characterized by inflammation and ulceration of the large intestine, is caused by infection with <i>Shigella</i> species. It is a major public health problem in developing countries where filthy sanitation practices and restricted access to clean water encourage the spread of the disease. Shigellosis is spread by means of fecal-oral route. It is one of the most common disorders specially affecting children in West Bengal, India. Disease from <i>Shigella</i> species accounts for 165 million cases of diarrhoea culminating in one million deaths annually worldwide. Severe dysentery is treated still with antibiotics, with limited success because of the continuous development of multi drug resistance by the bacteria. WHO has identified <i>Shigella</i> as a potential target pathogen against which new drugs need to be formulated and <i>in silico</i> approach has the potential to identify drug targets. Molecular modeling of <i>Shigella</i> invasion proteins using computational tools may divulge novel therapeutic targets that can be used for future pharmacological intervention. Detailed annotation of previously unknown Hypothetical Proteins using an <i>in-silico</i> pipeline can identify crucial proteins in pathogenesis cascade, which can be explored further as effective drug targets, which may eventually enable us to combat the menace of shigellosis." @default.
- W3025519056 created "2020-05-21" @default.
- W3025519056 creator A5005032890 @default.
- W3025519056 creator A5017266613 @default.
- W3025519056 creator A5078559520 @default.
- W3025519056 date "2020-01-01" @default.
- W3025519056 modified "2023-10-16" @default.
- W3025519056 title "<em>Shigella</em> pathogenesis: molecular and computational insights" @default.
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- W3025519056 doi "https://doi.org/10.3934/molsci.2020007" @default.
- W3025519056 hasPublicationYear "2020" @default.
- W3025519056 type Work @default.