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- W3025546666 abstract "The response to anti-vascular endothelial growth factor (VEGF) treatment is variable. It is generally measured in terms of changes in correlated functional and/or anatomical outcomes, and patients are then classified as optimal response, poor response and non-response. The precise cause of non-response remains undetermined. A variety of factors could account for poor or non-response to anti-VEGF therapy, such as age, baseline vision, disease course, lesion characteristics and genomic polymorphism. At the present time, many studies on the genetic factors of non-response or poor response to anti-VEGF treatment mainly focus on VEGF genes (VEGF-A, VEGFR-2), complement factor H (CFH), age-related maculopathy susceptibility 2 (LOC387715/ARMS2), high temperature factor A-1 (HTRA1), interleukin-related gene (IL-8 rs4073) and so forth. It is still worthy of further investigations that how to assess genetic reasons for non-response or poor response, so that we can provide individualized treatment sequences and predict the response to anti-VEGF therapy. (Chin J Ophthalmol, 2018, 54:873-878).抗血管内皮生长因子（VEGF）的疗效存在个体差异。根据功能及形态变化，抗VEGF治疗的应答程度可分为理想应答、弱应答、无应答3种情况。导致机体无应答的原因尚未明确，可能的影响因素包括年龄、基线视力、疾病病程、病灶特点及基因的多态性等。目前对于导致抗VEGF无应答遗传因素的研究主要集中在VEGF相关基因、补体因子H、年龄相关性黄斑病变易感因子2、高温必需因子A-1及白介素相关基因等。本文通过综合抗VEGF药物治疗无应答相关遗传学因素研究，进一步分析导致抗VEGF无应答的遗传机制，以期为临床制定个性化治疗方案和预测抗VEGF疗效研究提供参考。（中华眼科杂志，2018，54：873-878）." @default.
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- W3025546666 date "2018-11-11" @default.
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- W3025546666 title "[The genetic factors of non-response to anti-vascular endothelial growth factor therapy]." @default.
- W3025546666 doi "https://doi.org/10.3760/cma.j.issn.0412-4081.2018.11.016" @default.
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