Matches in SemOpenAlex for { <https://semopenalex.org/work/W3025577043> ?p ?o ?g. }
- W3025577043 endingPage "9065" @default.
- W3025577043 startingPage "9041" @default.
- W3025577043 abstract "Sigma non-opioid intracellular receptor 1 (sigma-1 receptor), a non-opioid transmembrane protein, is located on cellular mitochondrial membranes and endoplasmic reticulum. Current research has demonstrated that sigma-1 receptor is related to human degenerative diseases. This study is focused on the effects of sigma-1 receptor on the pathophysiological process of diminished ovarian reserve (DOR) and granulosa cells (GCs) apoptosis. Sigma-1 receptor concentration in follicular fluid (FF) and serum were negatively correlated with basal follicle-stimulating hormone (FSH) and positively correlated with anti-mullerian hormone (AMH), antral follicle count (AFC). Sigma-1 receptor reduction in GCs was accompanied by endoplasmic reticulum stress (ERS)-mediated apoptosis in women with DOR. Plasmid transfection was used to establish SIGMAR1-overexpressed and SIGMAR1-knockdown human granulosa-like tumor (KGN) cell and thapsigargin (TG) was used to induce ERS KGN cells. We found that KGN cells treated with endogenous sigma-1 receptor ligand dehydroepiandrosterone (DHEA) and sigma-1 receptor agonist PRE-084 showed similar biological effects to SIGMAR1-overexpressed KGN cells and opposite effects to SIGMAR1-knockdown KGN cells. DHEA may improve DOR patients' pregnancy outcomes by upregulating sigma-1 receptor and downregulating ERS-mediated apoptotic genes in GCs. Thus, sigma-1 receptor may be a potential ovarian reserve biomarker, and ligand-mediated sigma-1 receptor activation could be a future approach for DOR therapy." @default.
- W3025577043 created "2020-05-21" @default.
- W3025577043 creator A5005122608 @default.
- W3025577043 creator A5006077923 @default.
- W3025577043 creator A5011432307 @default.
- W3025577043 creator A5037709572 @default.
- W3025577043 creator A5045991882 @default.
- W3025577043 creator A5081209056 @default.
- W3025577043 creator A5088669852 @default.
- W3025577043 date "2020-05-14" @default.
- W3025577043 modified "2023-10-02" @default.
- W3025577043 title "Sigma-1 receptor is involved in diminished ovarian reserve possibly by influencing endoplasmic reticulum stress-mediated granulosa cells apoptosis" @default.
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