Matches in SemOpenAlex for { <https://semopenalex.org/work/W3025596927> ?p ?o ?g. }
- W3025596927 abstract "ABSTRACT The caecum, an intestinal appendage in the junction of the small and large intestines, displays a unique epithelium that serves as an exclusive niche for a range of pathogens including whipworms ( Trichuris spp ). While protocols to grow organoids from small intestine (enteroids) and colon (colonoids) exist, the conditions to culture organoids from the caecum have yet to be described. Here, we report methods to grow, differentiate and characterise mouse adult stem cell-derived caecal organoids, termed caecaloids. We compare the cellular composition of caecaloids to that of enteroids identifying differences in intestinal epithelial cell (IEC) populations that mimic those found in the caecum and small intestine. The remarkable similarity in the IECs composition and spatial conformation of caecaloids and their tissue of origin enables their use as an in vitro model to study host interactions with important caecal pathogens. Thus, exploiting this system we investigated the responses of caecal IECs to extracellular vesicles (EVs) secreted/excreted by the intracellular helminth Trichuris muris. Our findings reveal novel immunoregulatory effects of whipworm EVs on the caecal epithelium, including the downregulation of responses to nucleic acid recognition and type-I interferon (IFN) signalling." @default.
- W3025596927 created "2020-05-21" @default.
- W3025596927 creator A5007546839 @default.
- W3025596927 creator A5010553384 @default.
- W3025596927 creator A5016490989 @default.
- W3025596927 creator A5020826406 @default.
- W3025596927 creator A5026207705 @default.
- W3025596927 creator A5057653322 @default.
- W3025596927 creator A5065695073 @default.
- W3025596927 creator A5085874523 @default.
- W3025596927 creator A5088904415 @default.
- W3025596927 date "2020-05-12" @default.
- W3025596927 modified "2023-09-23" @default.
- W3025596927 title "Development of caecaloids to study host-pathogen interactions: new insights into immunoregulatory functions ofTrichuris murisextracellular vesicles in the caecum" @default.
- W3025596927 cites W1856217432 @default.
- W3025596927 cites W1926241811 @default.
- W3025596927 cites W1936575704 @default.
- W3025596927 cites W1965157206 @default.
- W3025596927 cites W1973067432 @default.
- W3025596927 cites W1980914602 @default.
- W3025596927 cites W1981068608 @default.
- W3025596927 cites W1997114875 @default.
- W3025596927 cites W1997679278 @default.
- W3025596927 cites W2002513358 @default.
- W3025596927 cites W2013350635 @default.
- W3025596927 cites W2023726755 @default.
- W3025596927 cites W2040936157 @default.
- W3025596927 cites W2043659905 @default.
- W3025596927 cites W2049356233 @default.
- W3025596927 cites W2052685738 @default.
- W3025596927 cites W2052891178 @default.
- W3025596927 cites W2067320696 @default.
- W3025596927 cites W2067710368 @default.
- W3025596927 cites W2067888624 @default.
- W3025596927 cites W2073608230 @default.
- W3025596927 cites W2091384393 @default.
- W3025596927 cites W2097387056 @default.
- W3025596927 cites W2103297591 @default.
- W3025596927 cites W2117317247 @default.
- W3025596927 cites W2124519481 @default.
- W3025596927 cites W2125198788 @default.
- W3025596927 cites W2137783202 @default.
- W3025596927 cites W2148103005 @default.
- W3025596927 cites W2169330513 @default.
- W3025596927 cites W2169405538 @default.
- W3025596927 cites W2171718924 @default.
- W3025596927 cites W2179438025 @default.
- W3025596927 cites W2282335838 @default.
- W3025596927 cites W2323326409 @default.
- W3025596927 cites W2548555233 @default.
- W3025596927 cites W2559535985 @default.
- W3025596927 cites W2562644378 @default.
- W3025596927 cites W2565359054 @default.
- W3025596927 cites W2587192575 @default.
- W3025596927 cites W2595836467 @default.
- W3025596927 cites W2607665808 @default.
- W3025596927 cites W2616566208 @default.
- W3025596927 cites W2618954565 @default.
- W3025596927 cites W2736197576 @default.
- W3025596927 cites W2790630598 @default.
- W3025596927 cites W2802510600 @default.
- W3025596927 cites W2802981078 @default.
- W3025596927 cites W2804802143 @default.
- W3025596927 cites W2889790357 @default.
- W3025596927 cites W2890360767 @default.
- W3025596927 cites W2896756677 @default.
- W3025596927 cites W2913284684 @default.
- W3025596927 cites W2917132599 @default.
- W3025596927 cites W2941080670 @default.
- W3025596927 cites W2947525400 @default.
- W3025596927 cites W2948307638 @default.
- W3025596927 cites W2950320278 @default.
- W3025596927 cites W2991287552 @default.
- W3025596927 cites W3006497234 @default.
- W3025596927 cites W3041764174 @default.
- W3025596927 doi "https://doi.org/10.1101/2020.05.11.087684" @default.
- W3025596927 hasPublicationYear "2020" @default.
- W3025596927 type Work @default.
- W3025596927 sameAs 3025596927 @default.
- W3025596927 citedByCount "1" @default.
- W3025596927 countsByYear W30255969272020 @default.
- W3025596927 crossrefType "posted-content" @default.
- W3025596927 hasAuthorship W3025596927A5007546839 @default.
- W3025596927 hasAuthorship W3025596927A5010553384 @default.
- W3025596927 hasAuthorship W3025596927A5016490989 @default.
- W3025596927 hasAuthorship W3025596927A5020826406 @default.
- W3025596927 hasAuthorship W3025596927A5026207705 @default.
- W3025596927 hasAuthorship W3025596927A5057653322 @default.
- W3025596927 hasAuthorship W3025596927A5065695073 @default.
- W3025596927 hasAuthorship W3025596927A5085874523 @default.
- W3025596927 hasAuthorship W3025596927A5088904415 @default.
- W3025596927 hasBestOaLocation W30255969271 @default.
- W3025596927 hasConcept C126322002 @default.
- W3025596927 hasConcept C2776460866 @default.
- W3025596927 hasConcept C2777882243 @default.
- W3025596927 hasConcept C2779861936 @default.
- W3025596927 hasConcept C2781077229 @default.
- W3025596927 hasConcept C2781317952 @default.
- W3025596927 hasConcept C3019368612 @default.
- W3025596927 hasConcept C31695470 @default.