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• W3025610901 abstract "Alterations of epigenetic proteins that modulate the gene repressive lysine 27 on histone H3 (H3K27me) are recurrent features in cancers, including multiple myeloma (MM). The histone demethylase UTX/KDM6A, mutated in up to 10% of cases of MM activates genes by removing the H3K27me3 repressive histone mark, counteracting EZH2. RNA-sequencing studies showed that UTX upregulated genes in association with loss of H3K27me. Treatment of MM cell lines with an EZH2 inhibitor preferentially slowed growth of UTX-null cells. EZH2 inhibitors activated many of the same genes as UTX but also induced the earlier stage B cell marker Bcl6 which, in turn, shut off the late B cell IRF4 and MYC, leading to cell death." @default.
• W3025610901 created "2020-05-21" @default.
• W3025610901 creator A5039865368 @default.
• W3025610901 date "2018-01-01" @default.
• W3025610901 modified "2023-09-23" @default.
• W3025610901 title "DISORDERED HISTONE METHYLATION IN HEMATOLOGICAL MALIGNANCIES THE CASE OF UTX/KDM6A." @default.
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• W3025610901 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6116604" @default.
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