FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3025622075> ?p ?o ?g. }

• W3025622075 endingPage "73" @default.
• W3025622075 startingPage "64" @default.
• W3025622075 abstract "T cells can help confer protective immunity by eliminating infections and tumors or drive immunopathology by damaging host cells. Both outcomes require a series of steps from the activation of naïve T cells to their clonal expansion, differentiation and migration to tissue sites. In addition to specific recognition of the antigen via the T cell receptor (TCR), multiple accessory signals from costimulatory molecules, cytokines and metabolites also influence each step along the progression of the T cell response. Current efforts to modify effector T cell function in many clinical contexts focus on the latter - which encompass antigen-independent and broad, contextual regulators. Not surprisingly, such approaches are often accompanied by adverse events, as they also affect T cells not relevant to the specific treatment. In contrast, fine tuning T cell responses by precisely targeting antigen-specific TCR signals has the potential to radically alter therapeutic strategies in a focused manner. Development of such approaches, however, requires a better understanding of functioning of the TCR and the biochemical signaling network coupled to it. In this article, we review some of the recent advances which highlight important roles of TCR signals throughout the activation and differentiation of T cells during an immune response. We discuss how, an appreciation of specific signaling modalities and variant ligands that influence the function of the TCR has the potential to influence design principles for the next generation of pharmacologic and cellular therapies, especially in the context of tumor immunotherapies involving adoptive cell transfers." @default.
• W3025622075 created "2020-05-21" @default.
• W3025622075 creator A5026251962 @default.
• W3025622075 creator A5091297121 @default.
• W3025622075 date "2020-07-01" @default.
• W3025622075 modified "2023-10-02" @default.
• W3025622075 title "Manipulating the TCR signaling network for cellular immunotherapy: Challenges & opportunities" @default.
• W3025622075 cites W1481172479 @default.
• W3025622075 cites W1492418658 @default.
• W3025622075 cites W1501496773 @default.
• W3025622075 cites W1502100938 @default.
• W3025622075 cites W1503844819 @default.
• W3025622075 cites W1509560407 @default.
• W3025622075 cites W1513014113 @default.
• W3025622075 cites W1517571912 @default.
• W3025622075 cites W1523489331 @default.
• W3025622075 cites W1528831675 @default.
• W3025622075 cites W1596079370 @default.
• W3025622075 cites W1608778557 @default.
• W3025622075 cites W1616490052 @default.
• W3025622075 cites W1644502582 @default.
• W3025622075 cites W174304716 @default.
• W3025622075 cites W1906616494 @default.
• W3025622075 cites W1910012553 @default.
• W3025622075 cites W1910384556 @default.
• W3025622075 cites W1943771969 @default.
• W3025622075 cites W1958443592 @default.
• W3025622075 cites W1971692004 @default.
• W3025622075 cites W1975568557 @default.
• W3025622075 cites W1984109590 @default.
• W3025622075 cites W1984781939 @default.
• W3025622075 cites W1985272248 @default.
• W3025622075 cites W1986189485 @default.
• W3025622075 cites W2001074195 @default.
• W3025622075 cites W2002351001 @default.
• W3025622075 cites W2004680217 @default.
• W3025622075 cites W2008354811 @default.
• W3025622075 cites W2009329366 @default.
• W3025622075 cites W2013798742 @default.
• W3025622075 cites W2018947464 @default.
• W3025622075 cites W2022480304 @default.
• W3025622075 cites W2036408747 @default.
• W3025622075 cites W2038108432 @default.
• W3025622075 cites W2038169247 @default.
• W3025622075 cites W2038421035 @default.
• W3025622075 cites W2039096179 @default.
• W3025622075 cites W2041226315 @default.
• W3025622075 cites W2041670467 @default.
• W3025622075 cites W2043793366 @default.
• W3025622075 cites W2046747425 @default.
• W3025622075 cites W2055567106 @default.
• W3025622075 cites W2060729327 @default.
• W3025622075 cites W2063116057 @default.
• W3025622075 cites W2064253793 @default.
• W3025622075 cites W2064593553 @default.
• W3025622075 cites W2065681262 @default.
• W3025622075 cites W2066698152 @default.
• W3025622075 cites W2066887263 @default.
• W3025622075 cites W2067064730 @default.
• W3025622075 cites W2068173904 @default.
• W3025622075 cites W2071019594 @default.
• W3025622075 cites W2073655356 @default.
• W3025622075 cites W2075453847 @default.
• W3025622075 cites W2075944172 @default.
• W3025622075 cites W2078307057 @default.
• W3025622075 cites W2078387056 @default.
• W3025622075 cites W2078780781 @default.
• W3025622075 cites W2089493370 @default.
• W3025622075 cites W2089676458 @default.
• W3025622075 cites W2093902610 @default.
• W3025622075 cites W2097855813 @default.
• W3025622075 cites W2099295104 @default.
• W3025622075 cites W2100510996 @default.
• W3025622075 cites W2103780522 @default.
• W3025622075 cites W2104345957 @default.
• W3025622075 cites W2104750134 @default.
• W3025622075 cites W2106758295 @default.
• W3025622075 cites W2107383854 @default.
• W3025622075 cites W2108524870 @default.
• W3025622075 cites W2108819594 @default.
• W3025622075 cites W2108909957 @default.
• W3025622075 cites W2110305039 @default.
• W3025622075 cites W2110459643 @default.
• W3025622075 cites W2110826122 @default.
• W3025622075 cites W2118613671 @default.
• W3025622075 cites W2119077423 @default.
• W3025622075 cites W2120813964 @default.
• W3025622075 cites W2122427042 @default.
• W3025622075 cites W2128106363 @default.
• W3025622075 cites W2130506153 @default.
• W3025622075 cites W2138477307 @default.
• W3025622075 cites W2139159445 @default.
• W3025622075 cites W2143772132 @default.
• W3025622075 cites W2144599081 @default.
• W3025622075 cites W2147885555 @default.
• W3025622075 cites W2148399431 @default.
• W3025622075 cites W2148712172 @default.
• W3025622075 cites W2148896940 @default.

• next