Matches in SemOpenAlex for { <https://semopenalex.org/work/W3025636421> ?p ?o ?g. }
- W3025636421 endingPage "508" @default.
- W3025636421 startingPage "495" @default.
- W3025636421 abstract "Numerous chemotypes have been described over time in order to generate potent and selective 5-HT4R ligands. Both agonists and antagonists have demonstrated their interest in several disease models. This culminates with the FDA approval of tegaserod and prucalopride in the recent years.This review summarizes the patent applications from 2014 to present, dedicated to the use or the description of novel 5-HT4R modulators. Several novel ligands and scaffolds have been industrially protected mainly in the field of central nervous system (CNS) pathologies as well as gastrointestinal disorders, including the combination with other drugs or for veterinary uses.The therapeutic potential of 5-HT4R modulators has been explored for several years in animal models, but also linked to potential safety issues with initial ligands. The current use of prucalopride in humans demonstrates that its toxicity is not linked to the target and that 5-HT4R modulators are safe in humans. Therefore, an important number of studies and patents has continued in the recent years to expand the use of 5-HT4R modulators, not only to treat gastrointestinal disorders, but also for CNS pathologies. This article details current efforts in this development." @default.
- W3025636421 created "2020-05-21" @default.
- W3025636421 creator A5018243857 @default.
- W3025636421 creator A5036678266 @default.
- W3025636421 creator A5058527420 @default.
- W3025636421 creator A5065180611 @default.
- W3025636421 creator A5077125444 @default.
- W3025636421 date "2020-06-18" @default.
- W3025636421 modified "2023-10-14" @default.
- W3025636421 title "Therapeutic modulators of the serotonin 5-HT<sub>4</sub> receptor: a patent review (2014-present)" @default.
- W3025636421 cites W1929267935 @default.
- W3025636421 cites W1997212073 @default.
- W3025636421 cites W1998450521 @default.
- W3025636421 cites W2002439590 @default.
- W3025636421 cites W2006686605 @default.
- W3025636421 cites W2010150387 @default.
- W3025636421 cites W2010861469 @default.
- W3025636421 cites W2013121971 @default.
- W3025636421 cites W2017831981 @default.
- W3025636421 cites W2018323656 @default.
- W3025636421 cites W2019562435 @default.
- W3025636421 cites W2025887031 @default.
- W3025636421 cites W2027719768 @default.
- W3025636421 cites W2037991163 @default.
- W3025636421 cites W2042544123 @default.
- W3025636421 cites W2043407651 @default.
- W3025636421 cites W2051508159 @default.
- W3025636421 cites W2052161713 @default.
- W3025636421 cites W2053124111 @default.
- W3025636421 cites W2054059195 @default.
- W3025636421 cites W2065532157 @default.
- W3025636421 cites W2067926306 @default.
- W3025636421 cites W2074493113 @default.
- W3025636421 cites W2081035442 @default.
- W3025636421 cites W2083090400 @default.
- W3025636421 cites W2083803246 @default.
- W3025636421 cites W2095302783 @default.
- W3025636421 cites W2127493455 @default.
- W3025636421 cites W2135987299 @default.
- W3025636421 cites W2165433821 @default.
- W3025636421 cites W2170892449 @default.
- W3025636421 cites W2185690353 @default.
- W3025636421 cites W2322676109 @default.
- W3025636421 cites W2334352131 @default.
- W3025636421 cites W2396935134 @default.
- W3025636421 cites W2421616427 @default.
- W3025636421 cites W2616789786 @default.
- W3025636421 cites W2770737274 @default.
- W3025636421 cites W2804564438 @default.
- W3025636421 cites W2949805077 @default.
- W3025636421 cites W2965647707 @default.
- W3025636421 cites W2974544318 @default.
- W3025636421 cites W2997007343 @default.
- W3025636421 cites W3007417551 @default.
- W3025636421 cites W3008886660 @default.
- W3025636421 cites W3014288215 @default.
- W3025636421 doi "https://doi.org/10.1080/13543776.2020.1767587" @default.
- W3025636421 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32400221" @default.
- W3025636421 hasPublicationYear "2020" @default.
- W3025636421 type Work @default.
- W3025636421 sameAs 3025636421 @default.
- W3025636421 citedByCount "12" @default.
- W3025636421 countsByYear W30256364212020 @default.
- W3025636421 countsByYear W30256364212021 @default.
- W3025636421 countsByYear W30256364212023 @default.
- W3025636421 crossrefType "journal-article" @default.
- W3025636421 hasAuthorship W3025636421A5018243857 @default.
- W3025636421 hasAuthorship W3025636421A5036678266 @default.
- W3025636421 hasAuthorship W3025636421A5058527420 @default.
- W3025636421 hasAuthorship W3025636421A5065180611 @default.
- W3025636421 hasAuthorship W3025636421A5077125444 @default.
- W3025636421 hasBestOaLocation W30256364212 @default.
- W3025636421 hasConcept C126322002 @default.
- W3025636421 hasConcept C169760540 @default.
- W3025636421 hasConcept C2778271842 @default.
- W3025636421 hasConcept C2781419993 @default.
- W3025636421 hasConcept C60644358 @default.
- W3025636421 hasConcept C71924100 @default.
- W3025636421 hasConcept C86803240 @default.
- W3025636421 hasConcept C98274493 @default.
- W3025636421 hasConceptScore W3025636421C126322002 @default.
- W3025636421 hasConceptScore W3025636421C169760540 @default.
- W3025636421 hasConceptScore W3025636421C2778271842 @default.
- W3025636421 hasConceptScore W3025636421C2781419993 @default.
- W3025636421 hasConceptScore W3025636421C60644358 @default.
- W3025636421 hasConceptScore W3025636421C71924100 @default.
- W3025636421 hasConceptScore W3025636421C86803240 @default.
- W3025636421 hasConceptScore W3025636421C98274493 @default.
- W3025636421 hasFunder F4320324479 @default.
- W3025636421 hasIssue "7" @default.
- W3025636421 hasLocation W30256364211 @default.
- W3025636421 hasLocation W30256364212 @default.
- W3025636421 hasLocation W30256364213 @default.
- W3025636421 hasLocation W30256364214 @default.
- W3025636421 hasLocation W30256364215 @default.
- W3025636421 hasLocation W30256364216 @default.
- W3025636421 hasOpenAccess W3025636421 @default.
- W3025636421 hasPrimaryLocation W30256364211 @default.