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- W3025646912 abstract "Abstract Ascomycota, the largest and best-studied phylum of fungi, contains three subphyla: Saccharomycotina (budding yeasts), Pezizomycotina (filamentous fungi), and Taphrinomycotina (fission yeasts); organisms from all three subphyla have been invaluable as models in diverse fields (e.g., biotechnology, cell biology, genetics, and medicine). Despite its importance, we still lack a comprehensive genome-scale phylogeny or understanding of the similarities and differences in the mode of genome evolution within this phylum. To address these gaps, we examined 1,107 genomes from Saccharomycotina (332), Pezizomycotina (761), and Taphrinomycotina (14) species to infer the Ascomycota phylogeny, estimate its timetree, and examine the evolution of key genomic properties. We inferred a robust genome-wide phylogeny that resolves several contentious relationships and estimated that the Ascomycota last common ancestor likely originated in the Ediacaran (~563 ± 68 million years ago). Comparisons of genomic properties revealed that Saccharomycotina and Pezizomycotina, the two taxon-rich subphyla, differed greatly in their genome properties. Saccharomycotina typically have smaller genomes, lower GC contents, lower numbers of genes, and higher rates of molecular sequence evolution compared to Pezizomycotina. Ancestral state reconstruction showed that the genome properties of the Saccharomycotina and Pezizomycotina last common ancestors were very similar, enabling inference of the direction of evolutionary change. For example, we found that a lineage-specific acceleration led to a 1.6-fold higher evolutionary rate in Saccharomycotina, whereas the 10% difference in GC content between Saccharomycotina and Pezizomycotina genomes stems from a trend toward AT bases within budding yeasts and toward GC bases within filamentous fungi. These results provide a robust evolutionary framework for understanding the diversification of the largest fungal phylum." @default.
- W3025646912 created "2020-05-21" @default.
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- W3025646912 date "2020-05-13" @default.
- W3025646912 modified "2023-10-18" @default.
- W3025646912 title "Genome-scale phylogeny and contrasting modes of genome evolution in the fungal phylum Ascomycota" @default.
- W3025646912 cites W1519676149 @default.
- W3025646912 cites W1605984840 @default.
- W3025646912 cites W1965381930 @default.
- W3025646912 cites W1972418962 @default.
- W3025646912 cites W1973175445 @default.
- W3025646912 cites W1983102293 @default.
- W3025646912 cites W1998671658 @default.
- W3025646912 cites W2013410948 @default.
- W3025646912 cites W2022203648 @default.
- W3025646912 cites W2025317241 @default.
- W3025646912 cites W2029271517 @default.
- W3025646912 cites W2032961150 @default.
- W3025646912 cites W2045017146 @default.
- W3025646912 cites W2054908644 @default.
- W3025646912 cites W2067644347 @default.
- W3025646912 cites W2098937968 @default.
- W3025646912 cites W2101291993 @default.
- W3025646912 cites W2108738426 @default.
- W3025646912 cites W2108795433 @default.
- W3025646912 cites W2109040034 @default.
- W3025646912 cites W2110335151 @default.
- W3025646912 cites W2111647009 @default.
- W3025646912 cites W2114828923 @default.
- W3025646912 cites W2115888213 @default.
- W3025646912 cites W2116402707 @default.
- W3025646912 cites W2116664360 @default.
- W3025646912 cites W2117260150 @default.
- W3025646912 cites W2123516016 @default.
- W3025646912 cites W2124790653 @default.
- W3025646912 cites W2139160625 @default.
- W3025646912 cites W2140148710 @default.
- W3025646912 cites W2141572089 @default.
- W3025646912 cites W2145562754 @default.
- W3025646912 cites W2146636518 @default.
- W3025646912 cites W2155113087 @default.
- W3025646912 cites W2159714622 @default.
- W3025646912 cites W2160378127 @default.
- W3025646912 cites W2163058500 @default.
- W3025646912 cites W2163627198 @default.
- W3025646912 cites W2165876708 @default.
- W3025646912 cites W2170817105 @default.
- W3025646912 cites W2171468101 @default.
- W3025646912 cites W2180107047 @default.
- W3025646912 cites W2277574918 @default.
- W3025646912 cites W2279493624 @default.
- W3025646912 cites W2288062690 @default.
- W3025646912 cites W2311203695 @default.
- W3025646912 cites W2393535458 @default.
- W3025646912 cites W2473558636 @default.
- W3025646912 cites W2512706593 @default.
- W3025646912 cites W2554017006 @default.
- W3025646912 cites W2559011563 @default.
- W3025646912 cites W2583458197 @default.
- W3025646912 cites W2587610309 @default.
- W3025646912 cites W2607411230 @default.
- W3025646912 cites W2747131829 @default.
- W3025646912 cites W2747215145 @default.
- W3025646912 cites W2747258456 @default.
- W3025646912 cites W2753424947 @default.
- W3025646912 cites W2754772205 @default.
- W3025646912 cites W2765226046 @default.
- W3025646912 cites W2766758647 @default.
- W3025646912 cites W2767639566 @default.
- W3025646912 cites W2783222708 @default.
- W3025646912 cites W2798064943 @default.
- W3025646912 cites W2801361050 @default.
- W3025646912 cites W2802109134 @default.
- W3025646912 cites W2804483100 @default.
- W3025646912 cites W2883251903 @default.
- W3025646912 cites W2899763402 @default.
- W3025646912 cites W2911336472 @default.
- W3025646912 cites W2938507534 @default.
- W3025646912 cites W2949367299 @default.
- W3025646912 cites W2949530903 @default.
- W3025646912 cites W2951257985 @default.
- W3025646912 cites W2970040898 @default.
- W3025646912 cites W2981543307 @default.
- W3025646912 cites W2982530416 @default.
- W3025646912 cites W2985567791 @default.
- W3025646912 cites W3004122056 @default.
- W3025646912 cites W3008467686 @default.
- W3025646912 cites W3010606899 @default.
- W3025646912 doi "https://doi.org/10.1101/2020.05.11.088658" @default.
- W3025646912 hasPublicationYear "2020" @default.
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