FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3025682899> ?p ?o ?g. }

• W3025682899 endingPage "104778" @default.
• W3025682899 startingPage "104778" @default.
• W3025682899 abstract "In oropharyngeal squamous cell carcinoma (OPSCC), toll-like receptors (TLR) 5 and 7 associate with the tumor’s human papilloma virus (HPV) status (Jouhi et al., 2017). TLR 2, on the other hand, has been linked to head and neck squamous cell carcinoma (HNSCC), and to oral carcinogenesis (Farnebo et al., 2015; Binder Gallimidi et al., 2015). Here we investigated the presence of TLR 2 and 4 in HPV-positive and HPV-negative OPSCC, and their relationship to opportunistic oral pathogen Treponema denticola chymotrypsin-like protease (Td-CTLP) immunoexpression, clinical parameters, and patient outcome. Clinicopathological data of 198 unselected consecutive OPSCC patients came from hospital registries. Immunoexpression of TLRs 2 and 4 we evaluated by immunohistochemistry, and earlier in this patient series we studied immunoexpression of Td-CTLP and HPV DNA, HPV mRNA, and p16 status. Immunoexpression of both TLRs 2 and 4 showed a significant association with HPV-status. Strong expression was associated with HPV-positivity and mild expression with HPV-negativity. Patients with strong TLR 2 immunoexpression in the HPV negative subgroup had significantly poorer 5-year DSS (58%) than did patients with mild TLR 2 expression (77%), and strong TLR 2 immunoexpression remained as an independent factor linked to increased disease mortality in the multivariable setting (P = 0.019). No association existed between TLR 2 or 4 and Td-CTLP expression. Our results support the role of TLR 2 receptor as a possible target for development of therapeutics as earlier proposed (Farnebo et al., 2015). The involvement of Td and other oral pathogens in carcinogenesis of OPSCC, remains open and calls for further study." @default.
• W3025682899 created "2020-05-21" @default.
• W3025682899 creator A5007965763 @default.
• W3025682899 creator A5009448794 @default.
• W3025682899 creator A5025687694 @default.
• W3025682899 creator A5027004045 @default.
• W3025682899 creator A5029013179 @default.
• W3025682899 creator A5030652209 @default.
• W3025682899 creator A5055369999 @default.
• W3025682899 creator A5061908744 @default.
• W3025682899 creator A5065156977 @default.
• W3025682899 date "2020-08-01" @default.
• W3025682899 modified "2023-09-30" @default.
• W3025682899 title "In HPV-negative oropharyngeal squamous cell carcinoma, elevated toll-like receptor 2 immunoexpression may increase the risk of disease-specific mortality" @default.
• W3025682899 cites W1517557449 @default.
• W3025682899 cites W1819421413 @default.
• W3025682899 cites W1942106386 @default.
• W3025682899 cites W1965702739 @default.
• W3025682899 cites W1971530363 @default.
• W3025682899 cites W1977122254 @default.
• W3025682899 cites W1979888611 @default.
• W3025682899 cites W2006292369 @default.
• W3025682899 cites W2011567073 @default.
• W3025682899 cites W2016292931 @default.
• W3025682899 cites W2020980399 @default.
• W3025682899 cites W2028196544 @default.
• W3025682899 cites W2041949509 @default.
• W3025682899 cites W2043191294 @default.
• W3025682899 cites W2057809738 @default.
• W3025682899 cites W2076219872 @default.
• W3025682899 cites W2101363646 @default.
• W3025682899 cites W2105214091 @default.
• W3025682899 cites W2110664940 @default.
• W3025682899 cites W2113791169 @default.
• W3025682899 cites W2114737175 @default.
• W3025682899 cites W2118927650 @default.
• W3025682899 cites W2134869568 @default.
• W3025682899 cites W2143680521 @default.
• W3025682899 cites W2144656526 @default.
• W3025682899 cites W2145736817 @default.
• W3025682899 cites W2148510247 @default.
• W3025682899 cites W2155808081 @default.
• W3025682899 cites W2160670021 @default.
• W3025682899 cites W2170178908 @default.
• W3025682899 cites W2343581255 @default.
• W3025682899 cites W2585129477 @default.
• W3025682899 cites W2620567597 @default.
• W3025682899 cites W2752155329 @default.
• W3025682899 cites W2770226065 @default.
• W3025682899 cites W2792233332 @default.
• W3025682899 cites W2794156984 @default.
• W3025682899 cites W2809490015 @default.
• W3025682899 cites W2919963266 @default.
• W3025682899 cites W2937980387 @default.
• W3025682899 cites W2946382837 @default.
• W3025682899 doi "https://doi.org/10.1016/j.oraloncology.2020.104778" @default.
• W3025682899 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32403078" @default.
• W3025682899 hasPublicationYear "2020" @default.
• W3025682899 type Work @default.
• W3025682899 sameAs 3025682899 @default.
• W3025682899 citedByCount "2" @default.
• W3025682899 countsByYear W30256828992021 @default.
• W3025682899 countsByYear W30256828992023 @default.
• W3025682899 crossrefType "journal-article" @default.
• W3025682899 hasAuthorship W3025682899A5007965763 @default.
• W3025682899 hasAuthorship W3025682899A5009448794 @default.
• W3025682899 hasAuthorship W3025682899A5025687694 @default.
• W3025682899 hasAuthorship W3025682899A5027004045 @default.
• W3025682899 hasAuthorship W3025682899A5029013179 @default.
• W3025682899 hasAuthorship W3025682899A5030652209 @default.
• W3025682899 hasAuthorship W3025682899A5055369999 @default.
• W3025682899 hasAuthorship W3025682899A5061908744 @default.
• W3025682899 hasAuthorship W3025682899A5065156977 @default.
• W3025682899 hasBestOaLocation W30256828992 @default.
• W3025682899 hasConcept C121608353 @default.
• W3025682899 hasConcept C126322002 @default.
• W3025682899 hasConcept C143998085 @default.
• W3025682899 hasConcept C203014093 @default.
• W3025682899 hasConcept C204232928 @default.
• W3025682899 hasConcept C2777422794 @default.
• W3025682899 hasConcept C2780183776 @default.
• W3025682899 hasConcept C2780385504 @default.
• W3025682899 hasConcept C502942594 @default.
• W3025682899 hasConcept C555283112 @default.
• W3025682899 hasConcept C71924100 @default.
• W3025682899 hasConceptScore W3025682899C121608353 @default.
• W3025682899 hasConceptScore W3025682899C126322002 @default.
• W3025682899 hasConceptScore W3025682899C143998085 @default.
• W3025682899 hasConceptScore W3025682899C203014093 @default.
• W3025682899 hasConceptScore W3025682899C204232928 @default.
• W3025682899 hasConceptScore W3025682899C2777422794 @default.
• W3025682899 hasConceptScore W3025682899C2780183776 @default.
• W3025682899 hasConceptScore W3025682899C2780385504 @default.
• W3025682899 hasConceptScore W3025682899C502942594 @default.
• W3025682899 hasConceptScore W3025682899C555283112 @default.
• W3025682899 hasConceptScore W3025682899C71924100 @default.
• W3025682899 hasLocation W30256828991 @default.
• W3025682899 hasLocation W30256828992 @default.

• next