Matches in SemOpenAlex for { <https://semopenalex.org/work/W3025704219> ?p ?o ?g. }
Showing items 1 to 76 of
76
with 100 items per page.
- W3025704219 endingPage "E642" @default.
- W3025704219 startingPage "E633" @default.
- W3025704219 abstract "The blood-brain barrier (BBB) is an important anatomical structure of the central nervous system (CNS) that limits the penetration of a variety of substances from the blood into the parenchyma. Dysfunction of the BBB is involved in various CNS disorders, including stroke, inflammation, and pain. However, the evidence concerning its role in migraine is insufficient.This study will investigate whether recurrent headache increases BBB permeability and vascular endothelial growth factor (VEGF) expression in a rat model.This study used an experimental design.The research took place in the Laboratory Research Center at The First Affiliated Hospital of Chongqing Medical University.Eighty male Sprague-Dawley rats were randomly divided into 3 groups: inflammatory soup (IS), control (PBS), and treatment (IS+Sumatriptan) groups. Recurrent headache was induced by episodic IS stimulation: 20 µL of IS were pumped into the dura 3 times per week in rats. The control group was administered 20 µL of PBS. The rats in the treatment group were simultaneously treated with sumatriptan (300 ug/kg, intraperitoneal) at the same time that IS was applied to the dura. Mechanical nociceptive thresholds were examined by electronic von Frey filaments with rigid tips. BBB permeability changes were measured with Evans blue (EB). The expression of VEGF was measured by double labeling and Western blotting.After 4 IS applications, the mechanical nociceptive thresholds significantly decreased. In addition, the mechanical hypersensitivity persisted for 4 hours after 9 applications. Only after 9 applications did the BBB permeability increase, as demonstrated by the EB tracer. The BBB disruption was accompanied by an elevation in VEGF expression. Sumatriptan treatment significantly reduced the mechanical hypersensitivity induced by IS stimulations and decreased the BBB disruption and VEGF expression.Potential mechanisms that underlie the relationship between BBB and VEGF were not examined in this study.The present study showed that repeated IS stimulations induced long-lasting allodynia, increased BBB permeability, and upregulated VEGF expression, all of which could be attenuated by early sumatriptan treatment.Migraine, inflammatory soup, blood-brain barrier, vascular endothelial growth factor, sumatriptan." @default.
- W3025704219 created "2020-05-21" @default.
- W3025704219 creator A5046045788 @default.
- W3025704219 creator A5066037624 @default.
- W3025704219 creator A5066666200 @default.
- W3025704219 creator A5091046473 @default.
- W3025704219 date "2018-11-01" @default.
- W3025704219 modified "2023-10-16" @default.
- W3025704219 title "Recurrent Headache Increases Blood-Brain Barrier Permeability and VEGF Expression in Rats." @default.
- W3025704219 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30508994" @default.
- W3025704219 hasPublicationYear "2018" @default.
- W3025704219 type Work @default.
- W3025704219 sameAs 3025704219 @default.
- W3025704219 citedByCount "3" @default.
- W3025704219 countsByYear W30257042192022 @default.
- W3025704219 countsByYear W30257042192023 @default.
- W3025704219 crossrefType "journal-article" @default.
- W3025704219 hasAuthorship W3025704219A5046045788 @default.
- W3025704219 hasAuthorship W3025704219A5066037624 @default.
- W3025704219 hasAuthorship W3025704219A5066666200 @default.
- W3025704219 hasAuthorship W3025704219A5091046473 @default.
- W3025704219 hasConcept C113045295 @default.
- W3025704219 hasConcept C126322002 @default.
- W3025704219 hasConcept C15490471 @default.
- W3025704219 hasConcept C167734588 @default.
- W3025704219 hasConcept C170493617 @default.
- W3025704219 hasConcept C24998067 @default.
- W3025704219 hasConcept C2776914184 @default.
- W3025704219 hasConcept C2777025900 @default.
- W3025704219 hasConcept C2777649898 @default.
- W3025704219 hasConcept C2778402981 @default.
- W3025704219 hasConcept C2778541695 @default.
- W3025704219 hasConcept C2778871607 @default.
- W3025704219 hasConcept C2778938600 @default.
- W3025704219 hasConcept C2780159080 @default.
- W3025704219 hasConcept C42219234 @default.
- W3025704219 hasConcept C529278444 @default.
- W3025704219 hasConcept C71924100 @default.
- W3025704219 hasConceptScore W3025704219C113045295 @default.
- W3025704219 hasConceptScore W3025704219C126322002 @default.
- W3025704219 hasConceptScore W3025704219C15490471 @default.
- W3025704219 hasConceptScore W3025704219C167734588 @default.
- W3025704219 hasConceptScore W3025704219C170493617 @default.
- W3025704219 hasConceptScore W3025704219C24998067 @default.
- W3025704219 hasConceptScore W3025704219C2776914184 @default.
- W3025704219 hasConceptScore W3025704219C2777025900 @default.
- W3025704219 hasConceptScore W3025704219C2777649898 @default.
- W3025704219 hasConceptScore W3025704219C2778402981 @default.
- W3025704219 hasConceptScore W3025704219C2778541695 @default.
- W3025704219 hasConceptScore W3025704219C2778871607 @default.
- W3025704219 hasConceptScore W3025704219C2778938600 @default.
- W3025704219 hasConceptScore W3025704219C2780159080 @default.
- W3025704219 hasConceptScore W3025704219C42219234 @default.
- W3025704219 hasConceptScore W3025704219C529278444 @default.
- W3025704219 hasConceptScore W3025704219C71924100 @default.
- W3025704219 hasIssue "6" @default.
- W3025704219 hasLocation W30257042191 @default.
- W3025704219 hasOpenAccess W3025704219 @default.
- W3025704219 hasPrimaryLocation W30257042191 @default.
- W3025704219 hasRelatedWork W193966656 @default.
- W3025704219 hasRelatedWork W1972875007 @default.
- W3025704219 hasRelatedWork W1974004912 @default.
- W3025704219 hasRelatedWork W1998594088 @default.
- W3025704219 hasRelatedWork W2160756066 @default.
- W3025704219 hasRelatedWork W2321726963 @default.
- W3025704219 hasRelatedWork W2343591787 @default.
- W3025704219 hasRelatedWork W2557533493 @default.
- W3025704219 hasRelatedWork W2898197629 @default.
- W3025704219 hasRelatedWork W292067595 @default.
- W3025704219 hasVolume "21" @default.
- W3025704219 isParatext "false" @default.
- W3025704219 isRetracted "false" @default.
- W3025704219 magId "3025704219" @default.
- W3025704219 workType "article" @default.