Matches in SemOpenAlex for { <https://semopenalex.org/work/W3025713031> ?p ?o ?g. }
- W3025713031 endingPage "799.e19" @default.
- W3025713031 startingPage "784" @default.
- W3025713031 abstract "Swelling of the brain or spinal cord (CNS edema) affects millions of people every year. All potential pharmacological interventions have failed in clinical trials, meaning that symptom management is the only treatment option. The water channel protein aquaporin-4 (AQP4) is expressed in astrocytes and mediates water flux across the blood-brain and blood-spinal cord barriers. Here we show that AQP4 cell-surface abundance increases in response to hypoxia-induced cell swelling in a calmodulin-dependent manner. Calmodulin directly binds the AQP4 carboxyl terminus, causing a specific conformational change and driving AQP4 cell-surface localization. Inhibition of calmodulin in a rat spinal cord injury model with the licensed drug trifluoperazine inhibited AQP4 localization to the blood-spinal cord barrier, ablated CNS edema, and led to accelerated functional recovery compared with untreated animals. We propose that targeting the mechanism of calmodulin-mediated cell-surface localization of AQP4 is a viable strategy for development of CNS edema therapies." @default.
- W3025713031 created "2020-05-21" @default.
- W3025713031 creator A5002833706 @default.
- W3025713031 creator A5009542352 @default.
- W3025713031 creator A5019284997 @default.
- W3025713031 creator A5020224635 @default.
- W3025713031 creator A5021397110 @default.
- W3025713031 creator A5024274003 @default.
- W3025713031 creator A5024646408 @default.
- W3025713031 creator A5028959960 @default.
- W3025713031 creator A5042190192 @default.
- W3025713031 creator A5042926722 @default.
- W3025713031 creator A5053315538 @default.
- W3025713031 creator A5056447859 @default.
- W3025713031 creator A5065040022 @default.
- W3025713031 creator A5068662415 @default.
- W3025713031 creator A5069302726 @default.
- W3025713031 creator A5073349579 @default.
- W3025713031 creator A5075665531 @default.
- W3025713031 creator A5085722901 @default.
- W3025713031 date "2020-05-01" @default.
- W3025713031 modified "2023-10-17" @default.
- W3025713031 title "Targeting Aquaporin-4 Subcellular Localization to Treat Central Nervous System Edema" @default.
- W3025713031 cites W131635192 @default.
- W3025713031 cites W1487472076 @default.
- W3025713031 cites W1495656315 @default.
- W3025713031 cites W1520528275 @default.
- W3025713031 cites W1558592232 @default.
- W3025713031 cites W1666691194 @default.
- W3025713031 cites W1757695926 @default.
- W3025713031 cites W1767701883 @default.
- W3025713031 cites W1818228426 @default.
- W3025713031 cites W1931574707 @default.
- W3025713031 cites W1966142173 @default.
- W3025713031 cites W1973656419 @default.
- W3025713031 cites W1977643725 @default.
- W3025713031 cites W1982532159 @default.
- W3025713031 cites W1982865246 @default.
- W3025713031 cites W1990891950 @default.
- W3025713031 cites W1997574055 @default.
- W3025713031 cites W1999340580 @default.
- W3025713031 cites W2003412986 @default.
- W3025713031 cites W2006004617 @default.
- W3025713031 cites W2006035554 @default.
- W3025713031 cites W2009851764 @default.
- W3025713031 cites W2010420138 @default.
- W3025713031 cites W2011252886 @default.
- W3025713031 cites W2011590904 @default.
- W3025713031 cites W2013113465 @default.
- W3025713031 cites W2021036163 @default.
- W3025713031 cites W2021786044 @default.
- W3025713031 cites W2029360750 @default.
- W3025713031 cites W2032021077 @default.
- W3025713031 cites W2035120744 @default.
- W3025713031 cites W2036924440 @default.
- W3025713031 cites W2039660551 @default.
- W3025713031 cites W2041419831 @default.
- W3025713031 cites W2052198628 @default.
- W3025713031 cites W2054538987 @default.
- W3025713031 cites W2057650991 @default.
- W3025713031 cites W2060701169 @default.
- W3025713031 cites W2060918019 @default.
- W3025713031 cites W2061517642 @default.
- W3025713031 cites W2066592562 @default.
- W3025713031 cites W2066606345 @default.
- W3025713031 cites W2067517471 @default.
- W3025713031 cites W2069342494 @default.
- W3025713031 cites W2072003572 @default.
- W3025713031 cites W2073329947 @default.
- W3025713031 cites W2075457027 @default.
- W3025713031 cites W2076015301 @default.
- W3025713031 cites W2077903158 @default.
- W3025713031 cites W2078936885 @default.
- W3025713031 cites W2084864775 @default.
- W3025713031 cites W2087851322 @default.
- W3025713031 cites W2091722185 @default.
- W3025713031 cites W2092066224 @default.
- W3025713031 cites W2092819402 @default.
- W3025713031 cites W2094566223 @default.
- W3025713031 cites W2101248665 @default.
- W3025713031 cites W2103511429 @default.
- W3025713031 cites W2105443363 @default.
- W3025713031 cites W2108469833 @default.
- W3025713031 cites W2114662739 @default.
- W3025713031 cites W2119067747 @default.
- W3025713031 cites W2119734225 @default.
- W3025713031 cites W2121740576 @default.
- W3025713031 cites W2144801767 @default.
- W3025713031 cites W2146762773 @default.
- W3025713031 cites W2150148667 @default.
- W3025713031 cites W2153759921 @default.
- W3025713031 cites W2154337429 @default.
- W3025713031 cites W2159640450 @default.
- W3025713031 cites W2165091323 @default.
- W3025713031 cites W2167020440 @default.
- W3025713031 cites W2168923611 @default.
- W3025713031 cites W2169821755 @default.
- W3025713031 cites W2171396834 @default.