Matches in SemOpenAlex for { <https://semopenalex.org/work/W3025746616> ?p ?o ?g. }
- W3025746616 endingPage "455" @default.
- W3025746616 startingPage "421" @default.
- W3025746616 abstract "The mammalian thioredoxins are a family of small (approximately 12 kDa) redox proteins that undergo NADPH-dependent reduction by thioredoxin reductase and in turn reduce oxidized cysteine groups on proteins. The two main thioredoxins are thioredoxin- 1, a cytosolic and nuclear form, and thioredoxin-2, a mitochondrial form. Thioredoxin-1 has been studied more. It performs many biological actions including the supply of reducing equivalents to thioredoxin peroxidases and ribonucleotide reductase, the regulation of transcription factor activity, and the regulation of enzyme activity by heterodimer formation. Thioredoxin-1 stimulates cell growth and is an inhibitor of apoptosis. Thioredoxins may play a role in a variety of human diseases including cancer. An increased level of thioredoxin-1 is found in many human tumors, where it is associated with aggressive tumor growth. Drugs are being developed that inhibit thioredoxin and that have antitumor activity." @default.
- W3025746616 created "2020-05-21" @default.
- W3025746616 creator A5011101496 @default.
- W3025746616 creator A5011988253 @default.
- W3025746616 date "2001-06-01" @default.
- W3025746616 modified "2023-10-18" @default.
- W3025746616 title "Properties and Biological Activities of Thioredoxins" @default.
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