FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3025768082> ?p ?o ?g. }

• W3025768082 abstract "Abstract Media preparation for perfusion cell culture processes contributes significantly to operational costs and the footprint of continuous operations for therapeutic protein manufacturing. In this study, definitions are given for the use of a perfusion equivalent nutrient feed stream which, when used in combination with basal perfusion medium, supplements the culture with targeted compounds and increases the medium depth. Definitions to compare medium and feed depth are given in this article. Using a concentrated nutrient feed, a 1.8‐fold medium consumption (MC) decrease and a 1.67‐fold increase in volumetric productivity (PR) were achieved compared to the initial condition. Later, this strategy was used to push cell densities above 100 × 10 6 cells/ml while using a perfusion rate below 2 RV/day. In this example, MC was also decreased 1.8‐fold compared to the initial condition, but due to the higher cell density, PR was increased 3.1‐fold and to an average PR value of 1.36 g L −1 day −1 during a short stable phase, and versus 0.46 g L −1 day −1 in the initial condition. Overall, the performance improvements were aligned with the given definitions. This multiple feeding strategy can be applied to gain some flexibility during process development and also in a manufacturing set‐up to enable better control on nutrient addition." @default.
• W3025768082 created "2020-05-21" @default.
• W3025768082 creator A5011454541 @default.
• W3025768082 creator A5027098263 @default.
• W3025768082 creator A5052197865 @default.
• W3025768082 creator A5074430879 @default.
• W3025768082 creator A5074762504 @default.
• W3025768082 date "2020-06-24" @default.
• W3025768082 modified "2023-10-17" @default.
• W3025768082 title "Reduction of medium consumption in perfusion mammalian cell cultures using a perfusion rate equivalent concentrated nutrient feed" @default.
• W3025768082 cites W1636483053 @default.
• W3025768082 cites W1967156755 @default.
• W3025768082 cites W1972080184 @default.
• W3025768082 cites W1995924547 @default.
• W3025768082 cites W2002725152 @default.
• W3025768082 cites W2014720377 @default.
• W3025768082 cites W2026756682 @default.
• W3025768082 cites W2029522334 @default.
• W3025768082 cites W2060805800 @default.
• W3025768082 cites W2061471252 @default.
• W3025768082 cites W2064463791 @default.
• W3025768082 cites W2109280317 @default.
• W3025768082 cites W2131774841 @default.
• W3025768082 cites W2147401031 @default.
• W3025768082 cites W2149834210 @default.
• W3025768082 cites W2289545277 @default.
• W3025768082 cites W232994572 @default.
• W3025768082 cites W2463313009 @default.
• W3025768082 cites W2604455630 @default.
• W3025768082 cites W2605426887 @default.
• W3025768082 cites W2611980186 @default.
• W3025768082 cites W2621387568 @default.
• W3025768082 cites W2756568237 @default.
• W3025768082 cites W2777998319 @default.
• W3025768082 cites W2781705479 @default.
• W3025768082 cites W2800033414 @default.
• W3025768082 cites W2800956912 @default.
• W3025768082 cites W2884264646 @default.
• W3025768082 cites W2885737412 @default.
• W3025768082 cites W2887576458 @default.
• W3025768082 cites W2917654936 @default.
• W3025768082 cites W2938797354 @default.
• W3025768082 cites W2942966135 @default.
• W3025768082 cites W2949488978 @default.
• W3025768082 cites W2960410044 @default.
• W3025768082 cites W594755807 @default.
• W3025768082 cites W599104063 @default.
• W3025768082 doi "https://doi.org/10.1002/btpr.3026" @default.
• W3025768082 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32415806" @default.
• W3025768082 hasPublicationYear "2020" @default.
• W3025768082 type Work @default.
• W3025768082 sameAs 3025768082 @default.
• W3025768082 citedByCount "8" @default.
• W3025768082 countsByYear W30257680822021 @default.
• W3025768082 countsByYear W30257680822022 @default.
• W3025768082 countsByYear W30257680822023 @default.
• W3025768082 crossrefType "journal-article" @default.
• W3025768082 hasAuthorship W3025768082A5011454541 @default.
• W3025768082 hasAuthorship W3025768082A5027098263 @default.
• W3025768082 hasAuthorship W3025768082A5052197865 @default.
• W3025768082 hasAuthorship W3025768082A5074430879 @default.
• W3025768082 hasAuthorship W3025768082A5074762504 @default.
• W3025768082 hasConcept C126322002 @default.
• W3025768082 hasConcept C127413603 @default.
• W3025768082 hasConcept C136229726 @default.
• W3025768082 hasConcept C140793950 @default.
• W3025768082 hasConcept C142796444 @default.
• W3025768082 hasConcept C146957229 @default.
• W3025768082 hasConcept C150903083 @default.
• W3025768082 hasConcept C185592680 @default.
• W3025768082 hasConcept C18903297 @default.
• W3025768082 hasConcept C192562407 @default.
• W3025768082 hasConcept C31903555 @default.
• W3025768082 hasConcept C33923547 @default.
• W3025768082 hasConcept C528095902 @default.
• W3025768082 hasConcept C71924100 @default.
• W3025768082 hasConcept C86803240 @default.
• W3025768082 hasConceptScore W3025768082C126322002 @default.
• W3025768082 hasConceptScore W3025768082C127413603 @default.
• W3025768082 hasConceptScore W3025768082C136229726 @default.
• W3025768082 hasConceptScore W3025768082C140793950 @default.
• W3025768082 hasConceptScore W3025768082C142796444 @default.
• W3025768082 hasConceptScore W3025768082C146957229 @default.
• W3025768082 hasConceptScore W3025768082C150903083 @default.
• W3025768082 hasConceptScore W3025768082C185592680 @default.
• W3025768082 hasConceptScore W3025768082C18903297 @default.
• W3025768082 hasConceptScore W3025768082C192562407 @default.
• W3025768082 hasConceptScore W3025768082C31903555 @default.
• W3025768082 hasConceptScore W3025768082C33923547 @default.
• W3025768082 hasConceptScore W3025768082C528095902 @default.
• W3025768082 hasConceptScore W3025768082C71924100 @default.
• W3025768082 hasConceptScore W3025768082C86803240 @default.
• W3025768082 hasIssue "5" @default.
• W3025768082 hasLocation W30257680821 @default.
• W3025768082 hasOpenAccess W3025768082 @default.
• W3025768082 hasPrimaryLocation W30257680821 @default.
• W3025768082 hasRelatedWork W1083927715 @default.
• W3025768082 hasRelatedWork W1660481199 @default.
• W3025768082 hasRelatedWork W1976370882 @default.
• W3025768082 hasRelatedWork W1998095097 @default.

• next