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- W3025774429 abstract "ABSTRACT ARHGAP36 is a Rho GTPase-activating protein (GAP) family member that contributes to spinal cord development and tumorigenesis. This multidomain protein is composed of splicing-dependent N-terminal sequences, the GAP-like region, and a unique C-terminal domain, and an N-terminal arginine-rich region has been shown to suppress protein kinase A (PKA) and activate Gli transcription factors. To understand how these structural elements act in concert, we have mapped the ARHGAP36 structure-activity landscape with domain- and amino-acid-level resolution. ARHGAP36-mediated Gli activation can be repressed by N-terminal sequences that regulate subcellular ARHGAP36 localization and PKA targeting. The GAP-like and C-terminal domains counteract this autoinhibitory mechanism and promote ARHGAP36 trafficking to the plasma membrane and primary cilium, respectively. The GAP-like domain may also conditionally suppress the arginine-rich region, and it modulates ARHGAP36 binding to the prolyl oligopeptidase-like protein PREPL and the E3 ubiquitin ligase PRAJA2. These domain-dependent activities provide a potential means for tissue-specific ARHGAP36 functions." @default.
- W3025774429 created "2020-05-21" @default.
- W3025774429 creator A5008558253 @default.
- W3025774429 creator A5018153402 @default.
- W3025774429 creator A5021367161 @default.
- W3025774429 creator A5028912845 @default.
- W3025774429 creator A5060815670 @default.
- W3025774429 creator A5068920596 @default.
- W3025774429 creator A5075340838 @default.
- W3025774429 date "2020-05-15" @default.
- W3025774429 modified "2023-10-18" @default.
- W3025774429 title "Multiple domains in ARHGAP36 regulate PKA degradation and Gli activation" @default.
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- W3025774429 doi "https://doi.org/10.1101/2020.05.14.094961" @default.
- W3025774429 hasPublicationYear "2020" @default.