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• W3025780760 endingPage "103815" @default.
• W3025780760 startingPage "103815" @default.
• W3025780760 abstract "Bovine mastitis, caused by Staphylococcus aureus, is a major impediment to milk production and lacks markers to indicate disease progression in cows and buffaloes. Thus, the focus of this study was to identify proteins marking the transition from subclinical to clinical mastitis. Whey proteins were isolated from 6 group's i.e. healthy, subclinical and clinical mastitis of Holstein Friesian cow and Murrah buffalo. Mass spectrometry and statistical analysis (ANOVA and t-tests) were performed on 12 biological samples each from cow and buffalo (4 per healthy, subclinical and clinical mastitis) resulting in a total of 24 proteome datasets. Collectively, 1479 proteins were identified of which significant proteins were shortlisted by a combination of fold change (≤ 0.5 or ≥ 2) and q < 0.05. Of these proteins, 128 and 163 indicated disease progression in cow and buffalo, respectively. Change in expression of haptoglobin and fibronectin from Holstein Friesian while spermadhesin and osteopontin from Murrah correlated with disease progression. Similarly, angiogenin and cofilin-1 were upregulated while ubiquitin family members were downregulated during disease transition. Subsequently, selected proteins (e.g. osteopontin and fibrinogen-α) were validated by Western blots. The results of this study provide deeper insights into whey proteome dynamics and signature patterns indicative of disease progression. Bovine mastitis is the most lethal infectious disease causing a huge economic loss in the dairy industry. In an attempt, to understand the dynamics of whey proteome in response to S. aureus infection, whey protein collected from healthy, subclinical and clinical mastitic HF and Mu were investigated. A total of 1479 proteins were identified, of which 128 and 163 had signature pattern in each stage indicative of the progression of the disease. The results of the present study provide a foundation to better understand the complexity of mastitis that will ultimately help facilitate early therapeutic and husbandry-based intervention to improve animal health and milk quality." @default.
• W3025780760 created "2020-05-21" @default.
• W3025780760 creator A5041405211 @default.
• W3025780760 creator A5049170030 @default.
• W3025780760 creator A5065143399 @default.
• W3025780760 date "2020-07-01" @default.
• W3025780760 modified "2023-10-18" @default.
• W3025780760 title "Quantitative alterations in bovine milk proteome from healthy, subclinical and clinical mastitis during S. aureus infection" @default.
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• W3025780760 doi "https://doi.org/10.1016/j.jprot.2020.103815" @default.
• W3025780760 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32423885" @default.
• W3025780760 hasPublicationYear "2020" @default.
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