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- W3025838260 abstract "ObjectiveTo investigate the clinical value of p16/Ki-67 immunocytochemistry in patients with atypical squamous cells of undetermined significance(ASC-US).MethodsOne hundred and seventy-one cases of thin-prep cytology test (TCT) diagnosed as ASC-US underwent p16/Ki-67 immunocytochemistry. All patients had colposcopy and biopsy from March 2015 to January 2016. Ninety of the 171 cases underwent high-risk HPV test at the same time.Resultsp16/Ki-67 immunocytochemistry was positive in 43.9% (75/171) of the 171 cytology samples; the sensitivity and specificity of p16/Ki-67 immunocytochemistry were 77.6%(52/67) and 77.9%(81/104) in detecting CIN2+ , and the positive and negative predictive value were 69.3%(52/75) and 84.4%(81/96), respectively. The sensitivity and specificity in diagnosing CIN2+ were 100.0%(34/34) and 10.7%(6/56) for HPV test, and the positive and negative predictive value were 40.5%(34/84) and 6/6. p16/Ki-67 immunocytochemistry showed lower sensitivity but obviously higher specificity than high-risk HPV detection.Conclusionp16/Ki-67 immunocytochemistry is a good triage test for identifying CIN2+ in ASC-US specimens.Key words: Cervical intraepithelial neoplasia; Cyclin-dependent kinase inhibitor p16; Ki-67 antigen; Human papillomavirus 16; Cytological techniques" @default.
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- W3025838260 date "2017-07-08" @default.
- W3025838260 modified "2023-09-26" @default.
- W3025838260 title "Application of p16/Ki-67 immunocytochemistry in triage of patients with atypical squamous cells of undetermined significance" @default.
- W3025838260 doi "https://doi.org/10.3760/cma.j.issn.0529-5807.2017.07.007" @default.
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