Matches in SemOpenAlex for { <https://semopenalex.org/work/W3025843910> ?p ?o ?g. }
- W3025843910 abstract "Abstract Antecedent viral infection may contribute to increased susceptibility to several neurological diseases, such as multiple sclerosis and Parkinson’s disease. Variation in clinical presentations of these diseases is often associated with gender, genetic background, or a combination of these and other factors. The complicated etiologies of these virally influenced diseases are difficult to study in conventional laboratory mouse models, which display a very limited number of phenotypes. We have used the genetically and phenotypically diverse Collaborative Cross mouse panel to examine complex neurological phenotypes after viral infection. Female and male mice from 18 CC strains were evaluated using a multifaceted phenotyping pipeline to define their unique disease profiles following infection with Theiler’s Murine Encephalomyelitis Virus, a neurotropic virus. We identified 4 distinct disease progression profiles based on limb-specific paresis and paralysis, tremors and seizures, and other clinical signs, along with separate gait profiles. We found that mice of the same strain had more similar profiles compared to those of different strains, and also identified strains and phenotypic parameters in which sex played a significant role in profile differences. These results demonstrate the value of using CC mice for studying complex disease subtypes influenced by sex and genetic background. Our findings will be useful for developing novel mouse models of virally induced neurological diseases with heterogenous presentation, an important step for designing personalized, precise treatments." @default.
- W3025843910 created "2020-05-21" @default.
- W3025843910 creator A5000947142 @default.
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- W3025843910 creator A5091455298 @default.
- W3025843910 date "2020-05-13" @default.
- W3025843910 modified "2023-10-02" @default.
- W3025843910 title "Antecedent presentation of neurological phenotypes in the Collaborative Cross reveals four classes with complex sex-dependencies" @default.
- W3025843910 cites W139404515 @default.
- W3025843910 cites W1491321203 @default.
- W3025843910 cites W1883267989 @default.
- W3025843910 cites W1926630196 @default.
- W3025843910 cites W1935254146 @default.
- W3025843910 cites W1964873974 @default.
- W3025843910 cites W1965942744 @default.
- W3025843910 cites W1966807310 @default.
- W3025843910 cites W1967938396 @default.
- W3025843910 cites W1972163933 @default.
- W3025843910 cites W1977920872 @default.
- W3025843910 cites W1980574125 @default.
- W3025843910 cites W1982661290 @default.
- W3025843910 cites W1987872249 @default.
- W3025843910 cites W1991249712 @default.
- W3025843910 cites W1992237817 @default.
- W3025843910 cites W1999191464 @default.
- W3025843910 cites W2004349171 @default.
- W3025843910 cites W2017675004 @default.
- W3025843910 cites W2024654003 @default.
- W3025843910 cites W2026937122 @default.
- W3025843910 cites W2033534190 @default.
- W3025843910 cites W2035373989 @default.
- W3025843910 cites W2042264991 @default.
- W3025843910 cites W2046451999 @default.
- W3025843910 cites W2048301875 @default.
- W3025843910 cites W2054930691 @default.
- W3025843910 cites W2056295046 @default.
- W3025843910 cites W2058219421 @default.
- W3025843910 cites W2064330095 @default.
- W3025843910 cites W2073445330 @default.
- W3025843910 cites W2075346916 @default.
- W3025843910 cites W2081394676 @default.
- W3025843910 cites W2083002110 @default.
- W3025843910 cites W2084435762 @default.
- W3025843910 cites W2087589796 @default.
- W3025843910 cites W2092300733 @default.
- W3025843910 cites W2098184616 @default.
- W3025843910 cites W2103946141 @default.
- W3025843910 cites W2104819392 @default.
- W3025843910 cites W2105206040 @default.
- W3025843910 cites W2107888974 @default.
- W3025843910 cites W2108726724 @default.
- W3025843910 cites W2109574134 @default.
- W3025843910 cites W2112765817 @default.
- W3025843910 cites W2114299067 @default.
- W3025843910 cites W2117804317 @default.
- W3025843910 cites W2119014382 @default.
- W3025843910 cites W2120007574 @default.
- W3025843910 cites W2120387391 @default.
- W3025843910 cites W2124033731 @default.
- W3025843910 cites W2130089704 @default.
- W3025843910 cites W2131271579 @default.
- W3025843910 cites W2133671490 @default.
- W3025843910 cites W2133707124 @default.
- W3025843910 cites W2134481863 @default.
- W3025843910 cites W2134587746 @default.
- W3025843910 cites W2138207763 @default.
- W3025843910 cites W2150606035 @default.
- W3025843910 cites W2154857902 @default.
- W3025843910 cites W2155286781 @default.
- W3025843910 cites W2156909607 @default.
- W3025843910 cites W2159874184 @default.
- W3025843910 cites W2161530562 @default.
- W3025843910 cites W2162074059 @default.
- W3025843910 cites W2166408412 @default.
- W3025843910 cites W2168283435 @default.
- W3025843910 cites W2169456326 @default.
- W3025843910 cites W2170585559 @default.
- W3025843910 cites W2178210969 @default.
- W3025843910 cites W2179438025 @default.
- W3025843910 cites W2250722538 @default.
- W3025843910 cites W2258193988 @default.
- W3025843910 cites W2326912412 @default.
- W3025843910 cites W2513766630 @default.
- W3025843910 cites W2518536270 @default.
- W3025843910 cites W2527832785 @default.
- W3025843910 cites W2618544227 @default.
- W3025843910 cites W2754218272 @default.
- W3025843910 cites W2758095848 @default.
- W3025843910 cites W2759026207 @default.
- W3025843910 cites W2786956288 @default.
- W3025843910 cites W2789726442 @default.
- W3025843910 cites W2884309857 @default.