Matches in SemOpenAlex for { <https://semopenalex.org/work/W3025853657> ?p ?o ?g. }
- W3025853657 endingPage "14" @default.
- W3025853657 startingPage "1" @default.
- W3025853657 abstract "Abstract Embryo–fetal exposure to bisphenol A (BPA) could be related to poor male reproductive parameters in rodents, but this concept has not been convincingly confirmed in humans. We investigated the association of environmental BPA exposure of pregnant women with selected endocrine and anthropometric parameters of male newborns. We analyzed plasma BPA from pregnant mothers, umbilical cord, and placental tissues ( n = 117/each group) by liquid chromatography and mass spectrometry. LH, FSH, AMH, TGFβ2, inhibin B, and selected sex steroids were measured in cord plasma. The infant anthropometric parameters included anogenital distance, stretched penile length, head circumference, birthweight, and length. The median BPA concentrations in maternal and umbilical cord plasma, and in placental tissue were 19.0, 8.0, and 22.2 nmol/L, respectively, the levels thus being over twofold lower in the fetal circulation than in the mother or placenta. The BPA concentrations measured were 100–1000-fold lower than those demonstrated in animal experiments to have endocrine disrupting effects. Multivariable regression analysis indicated no significant correlations between the maternal/fetal/placental BPA concentrations and any of the hormone levels or anthropometric parameter measured. Plasma concentrations of BPA confirmed both maternal, placenta, and fetal exposure to environmental BPA, but the concentrations were orders of magnitude lower than those with documented endocrine disrupting activity. Moreover, the maternal/fetal concentration gradient as well as the lack of correlations of BPA levels with any major endocrine or anthropometric parameters measured in the newborns suggest a protective role for the placenta in reducing fetal exposure to the environmental BPA." @default.
- W3025853657 created "2020-05-21" @default.
- W3025853657 creator A5016124717 @default.
- W3025853657 creator A5019379949 @default.
- W3025853657 creator A5022348579 @default.
- W3025853657 creator A5034030410 @default.
- W3025853657 creator A5034466104 @default.
- W3025853657 creator A5046521867 @default.
- W3025853657 creator A5047430062 @default.
- W3025853657 creator A5066771269 @default.
- W3025853657 creator A5068102907 @default.
- W3025853657 creator A5075441072 @default.
- W3025853657 creator A5078319475 @default.
- W3025853657 creator A5087158567 @default.
- W3025853657 creator A5088392007 @default.
- W3025853657 date "2020-05-15" @default.
- W3025853657 modified "2023-10-16" @default.
- W3025853657 title "Placenta is Capable of Protecting the Male Fetus from Exposure to Environmental Bisphenol A" @default.
- W3025853657 cites W1623762204 @default.
- W3025853657 cites W1953739912 @default.
- W3025853657 cites W1966684545 @default.
- W3025853657 cites W1967655383 @default.
- W3025853657 cites W1970358298 @default.
- W3025853657 cites W1970760886 @default.
- W3025853657 cites W1974503699 @default.
- W3025853657 cites W1975828516 @default.
- W3025853657 cites W1979440858 @default.
- W3025853657 cites W1982788880 @default.
- W3025853657 cites W1982868802 @default.
- W3025853657 cites W1984977749 @default.
- W3025853657 cites W1985063253 @default.
- W3025853657 cites W1987797208 @default.
- W3025853657 cites W1988194549 @default.
- W3025853657 cites W1989311232 @default.
- W3025853657 cites W1989755492 @default.
- W3025853657 cites W1990358624 @default.
- W3025853657 cites W1991473296 @default.
- W3025853657 cites W2001920946 @default.
- W3025853657 cites W2005427388 @default.
- W3025853657 cites W2006377417 @default.
- W3025853657 cites W2006512813 @default.
- W3025853657 cites W2006958457 @default.
- W3025853657 cites W2007888807 @default.
- W3025853657 cites W2008120843 @default.
- W3025853657 cites W2008951729 @default.
- W3025853657 cites W2013498844 @default.
- W3025853657 cites W2021604539 @default.
- W3025853657 cites W2024201289 @default.
- W3025853657 cites W2026180592 @default.
- W3025853657 cites W2029664629 @default.
- W3025853657 cites W2032743237 @default.
- W3025853657 cites W2037278965 @default.
- W3025853657 cites W2039027073 @default.
- W3025853657 cites W2040879761 @default.
- W3025853657 cites W2042150621 @default.
- W3025853657 cites W2048657217 @default.
- W3025853657 cites W2051496113 @default.
- W3025853657 cites W2063517792 @default.
- W3025853657 cites W2065707820 @default.
- W3025853657 cites W2065851428 @default.
- W3025853657 cites W2071684520 @default.
- W3025853657 cites W2072345180 @default.
- W3025853657 cites W2074305712 @default.
- W3025853657 cites W2075654456 @default.
- W3025853657 cites W2077182680 @default.
- W3025853657 cites W2081704559 @default.
- W3025853657 cites W2093574778 @default.
- W3025853657 cites W2093897650 @default.
- W3025853657 cites W2109879710 @default.
- W3025853657 cites W2110369682 @default.
- W3025853657 cites W2120816577 @default.
- W3025853657 cites W2127567198 @default.
- W3025853657 cites W2128021607 @default.
- W3025853657 cites W2132101535 @default.
- W3025853657 cites W2132457576 @default.
- W3025853657 cites W2134230184 @default.
- W3025853657 cites W2148090700 @default.
- W3025853657 cites W2152698697 @default.
- W3025853657 cites W2156556141 @default.
- W3025853657 cites W2162830803 @default.
- W3025853657 cites W2164889971 @default.
- W3025853657 cites W2170121431 @default.
- W3025853657 cites W2171423639 @default.
- W3025853657 cites W2189938228 @default.
- W3025853657 cites W2190800365 @default.
- W3025853657 cites W2205468003 @default.
- W3025853657 cites W2252652140 @default.
- W3025853657 cites W2286293453 @default.
- W3025853657 cites W2304666553 @default.
- W3025853657 cites W2324895181 @default.
- W3025853657 cites W2366486042 @default.
- W3025853657 cites W2395861701 @default.
- W3025853657 cites W2405124742 @default.
- W3025853657 cites W2507857762 @default.
- W3025853657 cites W2546641337 @default.
- W3025853657 cites W2568616540 @default.
- W3025853657 cites W2768541363 @default.
- W3025853657 cites W2793817212 @default.